Oral chronic graft-versus-host disease: analysis of dendritic cells subpopulations
| Autor: | Mair Pedro de Souza, Adauto José Ferreira Nunes, Érica Sinara Lenharo Orti-Raduan, Clara Marino Espricigo Botari, Ana Gabriela Salvio |
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| Přispěvatelé: | Hospital Fundação Amaral Carvalho, Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Myeloid Células dendríticas Biopsy medicine.medical_treatment Graft vs Host Disease Apoptosis Cell Count Hematopoietic stem cell transplantation Dermatology Dendritic cells Graft-versus-host disease Doença enxerto contra hospedeiro crônica Statistics Nonparametric Chronic disease Young Adult Antigen Antigens CD medicine Humans Mouth mucosa medicine.diagnostic_test business.industry Hematopoietic Stem Cell Transplantation Myeloid leukemia medicine.disease Immunohistochemistry Killer Cells Natural Dermatopathology Leukemia Myeloid Acute Leukemia Mucosa bucal medicine.anatomical_structure RL1-803 Immunology Female Interleukin-3 receptor business |
| Zdroj: | Anais Brasileiros de Dermatologia, Vol 89, Iss 4, Pp 632-637 (2014) Anais Brasileiros de Dermatologia Anais Brasileiros de Dermatologia, Volume: 89, Issue: 4, Pages: 632-637, Published: JUL 2014 Anais Brasileiros de Dermatologia v.89 n.4 2014 Anais brasileiros de dermatologia Sociedade Brasileira de Dermatologia (SBD) instacron:SBD Currículo Lattes Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 0365-0596 |
| Popis: | Made available in DSpace on 2016-04-01T18:46:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2014. Added 1 bitstream(s) on 2016-04-01T18:51:37Z : No. of bitstreams: 1 S0365-05962014000400632.pdf: 282148 bytes, checksum: 6f2e475a62b81e266a831de7b3bf229a (MD5) The graft-versus-host disease is the major cause of morbidity and mortality in patients who have undergone hematopoietic stem cell transplantation. Aiming at contributing to the understanding of the role of myeloid and plasmacytoid dendritic cells, and natural killer cells in chronic graft-versus-host disease, we examined biopsies of jugal mucosa of 26 patients with acute myeloid leukemia who had undergone allogenic hematopoietic stem cell transplantation. Half of these patients developed oral chronic graft-versus-host disease. Microscopic sections were immunohistochemically stained for anti-CD1a, anti-CD123 and anti-CD56. We calculated the number of immunostained cells in the corium per square millimeter and applied the Mann-Whitney test. Results showed a statistically significant increase of myeloid dendritic cells (CD1a+; p=0,02) and natural killer cells (CD56; p=0,04) in patients with oral chronic graft-versus-host disease. CD123 immunostaining showed no statistical difference between groups. It was concluded that myeloid dendritic cells and natural killer cells participate in the development of oral chronic graft-versus-host disease. Hospital Fundação Amaral Carvalho - Jaú (SP), Brazil Universidade Estadual Paulista "Júlio de Mesquita Filho", Programa de Pós-Graduação em Pesquisa e Desenvolvimento: Biotecnologia Médica, Faculdade de Medicina de Botucatu, Botucatu (SP), Brazil Universidade Estadual Paulista "Júlio de Mesquita Filho", Programa de Pós-Graduação em Pesquisa e Desenvolvimento: Biotecnologia Médica, Faculdade de Medicina de Botucatu, Botucatu (SP), Brazil |
| Databáze: | OpenAIRE |
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