Tissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma
| Autor: | Qing Wang, Lin C, Nan J, Yi Chu, Li Gong, Yining Yang, Lu Jg, Du Xl, Zang L, Qiao Q, Dong R, Xianli He |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Biochemistry Gastric adenocarcinoma Stomach Neoplasms Selenoprotein P medicine Humans Stage (cooking) Aged Neoplasm Staging Tumour node metastasis Tissue microarray integumentary system business.industry Stomach Biochemistry (medical) Case-control study Cell Biology General Medicine Middle Aged Immunohistochemistry digestive system diseases medicine.anatomical_structure Gastric Mucosa Tissue Array Analysis Case-Control Studies Female business |
| Zdroj: | The Journal of international medical research. 37(1) |
| ISSN: | 0300-0605 |
| Popis: | This study investigated selenoprotein P expression, using immunohistochemistry, in gastric adenocarcinoma tissue microarrays constructed from 30 gastric adenocarcinoma specimens and 30 normal gastric tissues (controls). Selenoprotein P expression scores were significantly lower in gastric adenocarcinoma (17/30, 56.7%) than in control tissues (25/30, 83.3%). Selenoprotein P was significantly more likely to be expressed in well-to-moderately differentiated cases (13/17, 76.5%) than in cases with low differentiation (4/13, 30.8%) and there was no significant difference in selenoprotein P expression between tumour node metastasis (TNM) stage I – II (11/19, 57.9%) and TNM stage III (6/11, 54.5%). In conclusion, selenoprotein P expression was low in gastric adenocarcinoma tissues compared with control tissues and was related to the degree of gastric adenocarcinoma differentiation but not to TNM stage. |
| Databáze: | OpenAIRE |
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