Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals
| Autor: | Timothy Lawlor, Kristien Mortelmans, Steve Haworth, Beth Anderson, Errol Zeiger |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Salmonella typhimurium endocrine system Salmonella Epidemiology Health Toxicology and Mutagenesis Group evaluation medicine.disease_cause Ames test Toxicology Cricetinae medicine Animals Food science Genetics (clinical) Syrian hamsters Mesocricetus Chemistry Mutagenicity Tests fungi food and beverages Rats Inbred Strains Rats Carcinogens Desiccator Mutagenicity Test Mutagens |
| Zdroj: | Environmental and molecular mutagenesis. 19 |
| ISSN: | 0893-6692 |
| Popis: | 311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters. Some of the volatile chemicals were also tested in desiccators. A total of 120 chemicals were mutagenic or weakly mutagenic, 3 were judged questionable, and 172 were non-mutagenic. The remaining 16 chemicals produced different responses in the two or three laboratories in which they were tested. The results and data from these tests are presented. |
| Databáze: | OpenAIRE |
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