4-Oxospiro[benzopyran-2,4′-piperidines] as selective α1a-adrenergic receptor antagonists

Autor:	Theodore P. Broten, Jill M. Erb, Mark G. Bock, Jennie B. Nerenberg, Raymond S.L. Chang, Jeffrey M. Bergman, Stacey O'Malley, Ann L. Scott
Rok vydání:	1999
Předmět:	Male Stereochemistry medicine.medical_treatment Clinical Biochemistry Prostatic Hyperplasia Pharmaceutical Science Adrenergic Antiarrhythmic agent Biochemistry Chemical synthesis Receptor subtype chemistry.chemical_compound Piperidines Drug Discovery medicine Animals Humans Benzopyrans Spiro Compounds Molecular Biology Organic Chemistry Antagonist In vitro Rats Benzopyran chemistry Adrenergic receptor antagonists Adrenergic alpha-1 Receptor Antagonists Molecular Medicine Anti-Arrhythmia Agents
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 9:291-294
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(98)00732-x
Popis:	The 4-oxospiro[benzopyran-2,4'-piperidine] ring system is contained within potent class III antiarrhythmic agents. We highlight how these agents can be chemically transformed into a new class of potent (1 nM) and selective (25-fold) alpha 1a-receptor subtype adrenergic antagonists.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38b11e6d14be9e2854308cc1d845fe8 https://doi.org/10.1016/s0960-894x(98)00732-x Zobrazit plný text záznamu Full Text from ScienceDirect