| Autor: |
Minton, Dennis M., Elliehausen, Christian J., Javors, Martin A., Santangelo, Kelly S., Konopka, Adam R. |
| Rok vydání: |
2022 |
| DOI: |
10.6084/m9.figshare.16767487.v2 |
| Popis: |
Additional file 1: Figure S1. OA pathology increased from 5- to 8-months of age. A) Representative histological images of the medial tibial plateu of the knee joint from 5- and 8-month-old guinea pigs (scale bars are 0.5mm and 0.25mm in 5x and 10x images, respectively). B) Images were graded for total OARSI score and individual OARSI criteria. Comparisons for ACS were made using the non-parametric Mann-Whitney test. C) the lateral tibial plateau, medial femoral condyle and lateral femoral condyle were also graded for total OARSI score. Data N = 3 for 5-month and N = 7 for 8-month. *P < 0.05 vs Con. Figure S2. Trabecular bone changes in response to experimental diets. Trabecular thickness (A), spacing (B), and bone volume fraction (C) were measured using microCT. N = 4 per group. *P < 0.05 vs Con. Figure S3. Antibody reactivity with guinea pig articular cartilage was limited. Immunohistochemical staining was performed, and no reactivity was observed using primary antibodies against P-Akt Ser473 or P-AMPK Thr172. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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