Standard addition method for the determination of pharmaceutical residues in drinking water by SPE–LC–MS/MS
| Autor: | André Crocq, Marguerite Lemasle, Isabelle Soutrel, Nicolas Cimetiere, Alain Laplanche |
|---|---|
| Přispěvatelé: | Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université européenne de Bretagne - European University of Brittany (UEB), Véolia Eau, Veolia, Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA) |
| Rok vydání: | 2013 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization 010501 environmental sciences Mass spectrometry Tandem mass spectrometry multiresidue analysis 01 natural sciences [CHIM.ANAL]Chemical Sciences/Analytical chemistry Water Quality Environmental Chemistry pharmaceutical compounds standard addition method Waste Management and Disposal 0105 earth and related environmental sciences Water Science and Technology Chromatography [SDE.IE]Environmental Sciences/Environmental Engineering Chemistry Water pollutants drinking water 010401 analytical chemistry Extraction (chemistry) ultra pressure liquid chromatography tandem mass spectrometry General Medicine 6. Clean water Spe lc ms ms 3. Good health 0104 chemical sciences Pharmaceutical Preparations Wastewater Standard addition Water treatment France Algorithms Water Pollutants Chemical Chromatography Liquid |
| Zdroj: | Environmental Technology Environmental Technology, 2013, pp.Published online. ⟨10.1080/09593330.2013.800563⟩ Environmental Technology, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2013, pp.Published online. ⟨10.1080/09593330.2013.800563⟩ |
| ISSN: | 1479-487X 0959-3330 |
| DOI: | 10.1080/09593330.2013.800563 |
| Popis: | International audience; The study of the occurrence and fate of pharmaceutical compounds in drinking or waste water processes has become very popular in recent years. Liquid chromatography with tandem mass spectrometry is a powerful analytical tool often used to determine pharmaceutical residues at trace level in water. However, many steps may disrupt the analytical procedure and bias the results. A list of 27 environmentally relevant molecules, including various therapeutic classes and (cardiovascular, veterinary and human antibiotics, neuroleptics, non-steroidal anti-inflammatory drugs, hormones and other miscellaneous pharmaceutical compounds), was selected. In this work, a method was developed using ultra performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) and solid-phase extraction to determine the concentration of the 27 targeted pharmaceutical compounds at the nanogram per litre level. The matrix effect was evaluated from water sampled at different treatment stages. Conventional methods with external calibration and internal standard correction were compared with the standard addition method (SAM). An accurate determination of pharmaceutical compounds in drinking water was obtained by the SAM associated with UPLC-MS/MS. The developed method was used to evaluate the occurrence and fate of pharmaceutical compounds in some drinking water treatment plants in the west of France. |
| Databáze: | OpenAIRE |
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