Sickle Cell Disease is Associated With Elevated Levels of Skin Advanced Glycation Endproducts
| Autor: | Renee Gardner, John Maynard, Liladhar Kashyap, Megan Ranck, Stuart A. Chalew, Abdulhameed Alsaheel |
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| Rok vydání: | 2018 |
| Předmět: |
Glycation End Products
Advanced Male medicine.medical_specialty Adolescent Cross-sectional study Bilirubin Anemia Renal function 030209 endocrinology & metabolism Anemia Sickle Cell 030204 cardiovascular system & hematology medicine.disease_cause Nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Reticulocyte Count Internal medicine medicine Humans Child Skin L-Lactate Dehydrogenase business.industry Hematology medicine.disease Hemolysis Black or African American Endocrinology Cross-Sectional Studies Oncology chemistry Creatinine Pediatrics Perinatology and Child Health Microalbuminuria Female business Oxidative stress Glomerular Filtration Rate |
| Zdroj: | Journal of pediatric hematology/oncology. 40(4) |
| ISSN: | 1536-3678 |
| Popis: | Sickle cell disease (SCD) is associated with increased oxidative stress which potentially enhances generation of advanced glycation endproducts (AGEs). We estimated skin accumulation of AGEs in SCD patients and assessed their relationship with hemolysis and nephropathy. Skin intrinsic fluorescence (SIF), an estimate of AGEs, was assessed in African American patients with and without SCD. After skin excitation with light at 375, 405, and 420 nm, raw autofluorescence was adjusted using specific intrinsic corrections. Group differences in SIF were evaluated by multiple variable regression using chronological age and sex as covariates. The relationship of SIF with reticulocyte count, serum lactate dehydrogenase, estimated glomerular filtration rate (GFR), plasma creatinine, bilirubin, and urine microalbumin was assessed. There were 48 SCD patients (29 male/19 female, age=13.4±3.6 y) and 51 controls (25 male/26 female, age=10.4±5.0 y). SIF375(1.0,0.0), SIF405(0.5,0.5), and SIF420(0.5,0.5) were significantly higher in SCD patients. There was no difference in SIF between SCD patients with and without microalbuminuria. SIF 420(0.5,0.5) was correlated with reticulocyte count (r=0.33; P=0.03). Skin AGEs as estimated by SIF were higher in children with SCD and weakly associated with 1 measure of hemolysis. Further study is needed to determine whether chronic increased deposition of AGEs is associated with development of complications of SCD. |
| Databáze: | OpenAIRE |
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