Reactive C cell hyperplasia as an incidental finding after thyroidectomy for papillary carcinoma
| Autor: | Vasiliki N. Soulou, Dimitrios K. Manatakis, Christodoulos Dimakis, Apostolos Bakavos, Sofia Tseleni-Balafouta |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Calcitonin Male endocrine system medicine.medical_specialty Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Comorbidity 030204 cardiovascular system & hematology Gastroenterology Thyroiditis Cohort Studies Thyroid carcinoma Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Postoperative Period Thyroid Neoplasms Thyroid cancer Aged Aged 80 and over Incidental Findings Hyperplasia Reactive C-Cell Hyperplasia business.industry Thyroid Thyroidectomy General Medicine Middle Aged medicine.disease Primary tumor medicine.anatomical_structure C-Cell Hyperplasia Thyroid Cancer Papillary Thyroid Epithelial Cells Female business |
| Zdroj: | Hormones. 18:289-295 |
| ISSN: | 2520-8721 1109-3099 |
| Popis: | The biologic and clinical significance of reactive C cell hyperplasia (CCH), adjacent to differentiated thyroid cancers, remains unknown. Our aim was to investigate the presence of CCH in thyroidectomy specimens with papillary thyroid carcinomas (PTC) and discuss its epidemiology and histology. In total, 413 patients were prospectively included in the study (189 benign goiters, 224 PTC). Reactive CCH was observed in 9.8% of PTC cases (32% males, 68% females, mean age 48.3 ± 16.4 years) and usually ipsilateral to the primary tumor (91%). Histologically, CCH was either focal (91%) or diffuse (9%) and almost always (92%) found in the middle or upper thirds of the thyroid lobes. Patients with PTC/CCH were generally younger than patients with benign goiters (0.027). On the other hand, patients with PTC and with PTC/CCH did not differ in terms of age, gender, basal calcitonin levels, primary tumor size, multifocality, extrathyroidal invasion, or lymph node metastasis. Thyroiditis, however, was more frequent in cases with PTC/CCH compared to PTC alone. Reactive CCH is considered a physiological response of the C cells to various stimuli, differentiated thyroid cancer among others. It bears no malignant potential and requires no additional treatment, following thyroidectomy. |
| Databáze: | OpenAIRE |
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