Oxidative Metabolism of Polymorphonuclear Leukocytes in Continuous Ambulatory Peritoneal Dialysis
| Autor: | Manabu Kuriyama, Yukimichi Kawada, Tsukasa Nagai |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Neutrophils medicine.medical_treatment 030232 urology & nephrology Serum albumin Peritonitis 030204 cardiovascular system & hematology Peritoneal dialysis 03 medical and health sciences 0302 clinical medicine Peritoneal Dialysis Continuous Ambulatory Risk Factors Internal medicine medicine Humans Dialysis Aged Whole blood biology business.industry Incidence Continuous ambulatory peritoneal dialysis General Medicine Middle Aged medicine.disease Endocrinology Nephrology Case-Control Studies Luminescent Measurements biology.protein Female Hemodialysis business Oxidation-Reduction Kidney disease |
| Zdroj: | Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 17:167-174 |
| ISSN: | 1718-4304 0896-8608 |
| Popis: | Objective To evaluate the oxidative metabolism of polymorphonuclear leukocytes (PMNL) in continuous ambulatory peritoneal dialysis (CAPD) patients compared with those of hemodialysis (HD) patients, chronic renal failure (CRF) patients not yet on dialysis, and healthy controls; and to discover factors contributing to the oxidative function in CAPD patients. Patients Thirty-five CAPD, 22 HD, 11 CRF patients were assessed; all were free from infections at the time of examination. Thirty-one healthy volunteers served as controls. Methods The oxidative metabolism was estimated by the production of superoxide anion, which was detected by luminol-dependent zymosan stimulated chemiluminescence (CL) with whole blood assessment. The volume of superoxide production equivalent to 1 mL of circulating blood (T-CL), that equivalent to 104 neutrophils (CL/N) and the velocity of superoxide production (V-CL), were measured as parameters for the oxidative function of PMNL. Results There were no differences in all CL parameters between CAPD and HD patients. T -CL and CL/N of dialysis patients were equal to controls but those of CRF patients were significantly decreased. V-CL of dialysis patients, as well as CRF patients, was smaller than that of controls but the difference was not significant. Among nutritional status, degree of anemia, dialytic efficacy and duration of dialysis in CAPD patients, only serum albumin concentration (Alb) correlated well to all CL parameters. Hypoalbuminemic patients(Alb Conclusions Oxidative metabolism of PMNL in CAPD patients was maintained with respect to superoxide productive volume, while the oxidative velocity was relatively impaired. Furthermore, it seems that albumin has a great influence on the oxidative metabolism of PMNL in CAPD patients. |
| Databáze: | OpenAIRE |
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