Natural killer cell receptor expression reflects the role of human cytomegalovirus in the pathogenesis of a subset of CD4+ T-cell large granular lymphocytosis
| Autor: | Francisco Ruiz-Cabello, Neus Romo, Anton W. Langerak, Dennis Tielemans, Miguel López-Botet, Andrea Sáez-Borderías, Julia Cantón |
|---|---|
| Přispěvatelé: | Immunology |
| Rok vydání: | 2011 |
| Předmět: |
CD4-Positive T-Lymphocytes
Lymphokine-activated killer cell ZAP70 Receptor expression Lymphocyte Immunology Cytomegalovirus Fluorescent Antibody Technique chemical and pharmacologic phenomena Lymphocytosis General Medicine Biology NKG2D Natural killer T cell Polymerase Chain Reaction Natural killer cell Interleukin 21 medicine.anatomical_structure SDG 3 - Good Health and Well-being medicine Humans Natural Killer T-Cells Receptors Natural Killer Cell Immunology and Allergy |
| Zdroj: | Human Immunology, 72(3), 226-228. Elsevier Inc. |
| ISSN: | 0198-8859 |
| Popis: | A high frequency of CD4(+) T-cell large granular lymphocyte (T-LGL) lymphocytosis occurs in human leukocyte antigen (HLA) -DRB1*0701 individuals displaying monoclonal expansions of V beta 13.1+ CD4(+) T-cell clones, which specifically respond to human cytomegalovirus (HCMV) antigens. We previously reported the expression of natural killer (NK)- cell associated receptors (NKR) by HCMV-specific cytolytic CD4(+) T cells from healthy donors. In the present study a high expression of different NKR (i.e., NKG2D, killer Ig-like receptors (KIR), CD94, ILT2) was observed in CD4(+) T cells from both V beta 13.1- and V beta 13.1+ CD4(+) T-LGL cases. Remarkably, elevated numbers of CD94/NKG2C+ NK cells, previously shown to expand in association to HCMV infection, were preferentially found in V beta 13.1+ T-LGL, further supporting its role in the pathogenesis of a subset of CD4(+) T-LGL (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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