Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma
| Autor: | Jin-Yu Wang, Yan Gao, Guang-Yan Yu, Min Gao, Xin Peng, Ruo-Lan Xiang, Xin Cong, Ning-Yan Yang, Xiao-Hong Guo, Sheng-Lin Li, Li Li, Xiao-Yan Xu, Li-Ling Wu |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Cell Growth Processes Biology medicine.disease_cause Decreased adiponectin level Western blot Cell Movement Risk Factors Cell Line Tumor Internal medicine medicine Humans Stage (cooking) Receptor medicine.diagnostic_test Adiponectin nutritional and metabolic diseases Original Articles General Medicine Middle Aged Tongue Neoplasms Phenotype Endocrinology Oncology Case-Control Studies Lymphatic Metastasis Carcinoma Squamous Cell Immunohistochemistry Biomarker (medicine) Female Receptors Adiponectin Carcinogenesis hormones hormone substitutes and hormone antagonists |
| Zdroj: | Cancer Sci |
| ISSN: | 1347-9032 |
| DOI: | 10.1111/cas.12077 |
| Popis: | Circulating adiponectin levels are inversely associated with risk of various obesity‐related cancers. However, the effect of adiponectin on carcinogenesis and progression of tongue squamous cell carcinoma (TSCC) remains unknown. We measured serum adiponectin levels in 59 patients with TSCC and 50 healthy controls. Expression of adiponectin and its receptors in paired tumor and paracancerous specimens were determined by immunohistochemical staining (n = 37) and western blot (n = 30), respectively. Serum adiponectin level was lower in patients than in controls (5.0 ± 2.4 vs 8.4 ± 3.5 μg/mL, P |
| Databáze: | OpenAIRE |
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