External photon radiation treatment for prostate cancer: Uncomplicated and cancer-free control probability assessment of 36 plans

Autor: Francisco Sánchez-Doblado, J.A. Terrón, M T García Hernández, D. Planes, L. Irazola, Joan Roselló, Juan Carlos Rodríguez Mateos, Marta Paiusco, M. Romero-Expósito, Beatriz Sánchez-Nieto
Přispěvatelé: Pontificia Universidad Católica de Chile, Banco Santander, Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Comisión Nacional de Investigación Científica y Tecnológica (Chile)
Rok vydání: 2019
Předmět:
Male
Probability assessment
medicine.medical_treatment
Radiobiological modelling
Biophysics
General Physics and Astronomy
Prostate radiotherapy treatment
Normal tissue complication probability
Tumour control probability
Radiation protection of the patient
030218 nuclear medicine & medical imaging
03 medical and health sciences
Prostate cancer
0302 clinical medicine
medicine
Humans
Dosimetry
Radiology
Nuclear Medicine and imaging
Conformal radiation
Probability
Photons
business.industry
Radiotherapy Planning
Computer-Assisted
Cancer-Free
Photon radiation
Prostatic Neoplasms
Radiotherapy Dosage
General Medicine
Second primary cancer
medicine.disease
Radiation therapy
Second primary cancer risk
030220 oncology & carcinogenesis
Radiotherapy plan optimisation
Radiotherapy
Intensity-Modulated
Radiotherapy
Conformal
Tomography
X-Ray Computed
Nuclear medicine
business
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
ISSN: 1120-1797
Popis: [Purpose] To perform a systematic and thorough assessment, using the Uncomplicated and Cancer-Free Control Probability (UCFCP) function, of a broad range of photon prostate cancer RT treatments, on the same scenario (a unique pelvic CT set). UCFCP considers, together with the probabilities of local tumour control (TCP) and deterministic (late) sequelae (NTCP), the second primary cancer risk (SPCR) due to photon and neutron peripheral doses.
[Methods and materials] Thirty-six radiotherapy plans were produced for the same CT. 6, 10, 15 and 18 MV 3DCRT, IMRT and VMAT (77.4 Gy in 43 fractions) and 6 and 10 MV SBRT (36.25 Gy in 5 fractions with flattened and FFF beams) for Elekta, Siemens and Varian Linacs plans were included. DVH and peripheral organ dosimetry were used to compute TCP, NTCP, and SPCR (the competition and LNT models) for further plan ranking.
[Results] Biological models (and parameters) used predicted an outcome which is in agreement with epidemiological findings. SBRT plans showed the lowest SPCR and a below average NTCPrectal. High energy plans did not rank worse than the low energy ones. Intensity modulated plans were ranked above the 3D conformal techniques.
[Conclusions] According to UCFCP, the best plans were the10 MV SBRTs. SPCR rates were low and did not show a substantial impact on plan ranking. High energy intensity-modulated plans did not increase in excess the average of SPCR. Even more, they ranked among the best, provided that MU were efficiently managed.
BSN acknowledges the support of Conicyt FONDECYT Regular 2018 (N1181133) and of Pontificia Universidad Católica de Chile [EPB2016, P1702/2017 and “Concurso de Apoyo a Sabáticos Internacionales 2017”]. MRE would like to thank Banco Santander for its support through the grant program ‘‘Becas Iberoamérica. Jóvenes Profesores e Investigadores y Alumnos de Doctorado Santander Universidad”.
Databáze: OpenAIRE
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