Persistence of Measles, Mumps, and Rubella Antibodies in an MMR‐Vaccinated Cohort: A 20‐Year Follow‐up
| Autor: | Mia Broman, Pauli Leinikki, Irja Davidkin, Heikki Peltola, Sari Jokinen |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Time Factors Measles-Mumps-Rubella Vaccine Immunization Secondary Antibodies Viral MMR vaccine Measles Rubella Cohort Studies Immunoenzyme Techniques 03 medical and health sciences 0302 clinical medicine medicine Humans Immunology and Allergy 030212 general & internal medicine Child Mumps Finland Mouth 0303 health sciences 030306 microbiology business.industry Infant medicine.disease Virology 3. Good health Vaccination Infectious Diseases Immunization Immunology Cohort Female Viral disease business Follow-Up Studies |
| Zdroj: | The Journal of Infectious Diseases. 197:950-956 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/528993 |
| Popis: | Background The persistence of antibodies against measles, mumps, and rubella induced by the measles-mumps-rubella (MMR) vaccine and the kinetics of antibody decline after the second MMR vaccine dose were studied in the same cohort for 20 years. Methods Measles, mumps, and rubella antibodies were measured by enzyme immunoassay in 20-year follow-up serum samples (n= 183) of twice-vaccinated individuals, and measles antibodies were also measured in oral fluids (n = 177). Antibody decay was determined in a group (n = 58) with subsequent samples collected 1, 8, and 15 years after the second MMR dose. Results In total, 95%, 74%, and 100% of 183 vaccinees were still seropositive for measles, mumps, and rubella, respectively, and 85% of 177 vaccinees had measurable measles antibodies in their oral fluids. The antibody levels declined significantly after the second dose, but subsequently the rate of decline was slower. Conclusions A high rate of seropositivity was found 20 years after the first MMR dose, particularly for rubella and measles. Our results show that MMR vaccine-induced antibodies wane significantly after the second dose. According to epidemiological data, the protection induced by MMR vaccination in Finland seems to persist at least until early adulthood. However, the situation requires constant vigilance. |
| Databáze: | OpenAIRE |
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