Development of Biopolymeric Hybrid Scaffold-Based on AAc/GO/nHAp/TiO2 Nanocomposite for Bone Tissue Engineering: In-Vitro Analysis
| Autor: | Hassan Mehboob, Mona Saad Binkadem, Rashid Amin, Wafa Shamsan Al-Arjan, Adnan Haider, Saiful Izwan Abd Razak, Mohsin Ali Raza, Muhammad U. Khan, Anwarul Hasan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Biocompatibility General Chemical Engineering Nanoparticle Bioceramic Bone tissue biodegradation chemistry.chemical_compound biocompatibility Tissue engineering medicine General Materials Science Porosity QD1-999 Acrylic acid Nanocomposite nanocomposite technology industry and agriculture Chemistry medicine.anatomical_structure chemistry Chemical engineering tissue engineering drug delivery cytotoxicity graphene oxide hybrid scaffolds |
| Zdroj: | Nanomaterials, Vol 11, Iss 1319, p 1319 (2021) Nanomaterials Volume 11 Issue 5 |
| ISSN: | 2079-4991 |
| Popis: | Bone tissue engineering is an advanced field for treatment of fractured bones to restore/regulate biological functions. Biopolymeric/bioceramic-based hybrid nanocomposite scaffolds are potential biomaterials for bone tissue because of biodegradable and biocompatible characteristics. We report synthesis of nanocomposite based on acrylic acid (AAc)/guar gum (GG), nano-hydroxyapatite (HAp NPs), titanium nanoparticles (TiO2 NPs), and optimum graphene oxide (GO) amount via free radical polymerization method. Porous scaffolds were fabricated through freeze-drying technique and coated with silver sulphadiazine. Different techniques were used to investigate functional group, crystal structural properties, morphology/elemental properties, porosity, and mechanical properties of fabricated scaffolds. Results show that increasing amount of TiO2 in combination with optimized GO has improved physicochemical and microstructural properties, mechanical properties (compressive strength (2.96 to 13.31 MPa) and Young’s modulus (39.56 to 300.81 MPa)), and porous properties (pore size (256.11 to 107.42 μm) and porosity (79.97 to 44.32%)). After 150 min, silver sulfadiazine release was found to be ~94.1%. In vitro assay of scaffolds also exhibited promising results against mouse pre-osteoblast (MC3T3-E1) cell lines. Hence, these fabricated scaffolds would be potential biomaterials for bone tissue engineering in biomedical engineering. |
| Databáze: | OpenAIRE |
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