Experiences with a new high-dose-rate brachytherapy (HDR-BT) boost technique for T3b prostate cancer
| Autor: | Steven E. Schild, Jochen Walz, Markus Graefen, Winfried Alberti, Juergen Dunst, Horst Thurmann, Dirk Rades, Rudolf Schwarz, M. Todorovic |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Brachytherapy Urology Prostate cancer Prostate medicine Humans Radiology Nuclear Medicine and imaging Proctitis Aged Aged 80 and over business.industry Dose fractionation Prostatic Neoplasms Dose-Response Relationship Radiation Radiotherapy Dosage medicine.disease Acute toxicity High-Dose Rate Brachytherapy Radiation therapy medicine.anatomical_structure Treatment Outcome Oncology Dose Fractionation Radiation Neoplasm Recurrence Local business |
| Zdroj: | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. 183(7) |
| ISSN: | 1439-099X |
| Popis: | Experiences with a new high-dose-rate brachytherapy (HDR-BT) boost technique in 41 patients with stage T3b prostate cancer are presented.The patients received 18 Gy of HDR-BT (9 Gy on days 1 + 8) plus 50.4 Gy of EBRT. 20 patients (group A) had BT applicators placed into the prostate alone resulting in 18 Gy to prostate and 0 Gy (tip) to 12 Gy (base) to seminal vesicles (SV). The cumulative EQD2 (equivalent dose in 2-Gy fractions, alpha/beta 1.5 Gy) to the SV was 47.5-73.3 Gy. 21 patients (group B) had BT applicators placed into both prostate and SV resulting in 18 Gy to prostate and to80% (but not 100%) of the SV (cumulative EQD2 81.5-101.5 Gy). Both groups were compared for acute and late toxicity and for biochemical relapse-free survival (bRFS).The 3-year bRFS was 57% for group A and 79% for group B patients (p = 0.29). A grade 3 acute toxicity (CTC 2.0) was not observed. Grade 2 acute toxicity (proctitis, cystitis, skin toxicity) was comparable in both groups. A grade 3 late toxicity did not occur. Impotence rates were 35% in group A and 24% in group B, respectively (p = 0.73).The new HDR-BT technique (group B) was associated only with minor acute and late toxicity and appears to result in better bRFS than the conventional HDR-BT technique (group A). The results must be confirmed in a prospective trial. |
| Databáze: | OpenAIRE |
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