Perspective: Moving Toward Desirable Linoleic Acid Content in Infant Formula
| Autor: | Stewart Forsyth, Marieke Abrahamse-Berkeveld, Beverly S. Muhlhausler, Philippe Legrand, Bert J. M. van de Heijning, Eline M. van der Beek, Susan E. Carlson, J. Thomas Brenna, Philip C. Calder, Berthold Koletzko, Carlo Agostoni, Lidewij Schipper |
|---|---|
| Přispěvatelé: | Reproductive Origins of Adult Health and Disease (ROAHD), Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Rok vydání: | 2021 |
| Předmět: |
linoleic acid
0301 basic medicine Intervention trials infant development Linoleic acid Medicine (miscellaneous) 030209 endocrinology & metabolism Functional health law.invention AcademicSubjects/MED00060 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine law Environmental health human milk composition Humans Medicine Infant Nutritional Physiological Phenomena 030109 nutrition & dietetics Nutrition and Dietetics Milk Human business.industry Perspective (graphical) Nutritional Requirements Infant infant formula Research needs Infant formula chemistry Perspective CLARITY Narrative review LCPUFAs nutritional programming business Food Science |
| Zdroj: | Advances in Nutrition Advances in nutrition, 12(6), 2085-2098. AMER SOC NUTRITION-ASN |
| ISSN: | 2161-8313 |
| DOI: | 10.1093/advances/nmab076 |
| Popis: | Infant formula should provide the appropriate nutrients and adequate energy to facilitate healthy infant growth and development. If conclusive data on quantitative nutrient requirements are not available, the composition of human milk (HM) can provide some initial guidance on the infant formula composition. This paper provides a narrative review of the current knowledge, unresolved questions, and future research needs in the area of HM fatty acid (FA) composition, with a particular focus on exploring appropriate intake levels of the essential FA linoleic acid (LA) in infant formula. The paper highlights a clear gap in clinical evidence as to the impact of LA levels in HM or formula on infant outcomes, such as growth, development, and long-term health. The available preclinical information suggests potential disadvantages of high LA intake in the early postnatal period. We recommend performing well-designed clinical intervention trials to create clarity on optimal levels of LA to achieve positive impacts on both short-term growth and development and long-term functional health outcomes. Statement of Significance: The present work summarizes and discusses for the first time the (gaps in) available evidence on the effects of linoleic acid in an infant diet on infant health outcomes in relation to the recently adapted changes in regulations for the addition of linoleic acid to infant formula. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|