Preclinical models for the study of Barrett's carcinogenesis
| Autor: | Wayne A. Phillips, Matthew Read, Nicholas J. Clemons, Kausilia K. Krishnadath |
|---|---|
| Přispěvatelé: | CCA - Cancer biology and immunology, Gastroenterology and Hepatology, AGEM - Re-generation and cancer of the digestive system |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Esophageal Neoplasms
Carcinogenesis Esophageal adenocarcinoma Adenocarcinoma medicine.disease_cause Bioinformatics General Biochemistry Genetics and Molecular Biology Barrett Esophagus 03 medical and health sciences 0302 clinical medicine History and Philosophy of Science medicine Animals Humans Disease process business.industry General Neuroscience Precursor lesion Neoplasms Experimental medicine.disease 030220 oncology & carcinogenesis Barrett's esophagus Columnar Metaplasia 030211 gastroenterology & hepatology business |
| Zdroj: | Annals of the New York Academy of Sciences, 1434(1), 139-148. Wiley-Blackwell |
| ISSN: | 0077-8923 |
| Popis: | Barrett's esophagus (BE) is clinically significant, as it is the only known precursor lesion for esophageal adenocarcinoma. To develop improved therapies for the treatment of BE, a greater understanding of the disease process at the molecular genetic level is needed. However, achieving a greater understanding will require improved preclinical models so that the disease process can be more closely studied and novel therapies can be tested. Our concise review highlights progress in the development of preclinical models for the study of BE and identifies the most suitable model in which to test novel therapies. |
| Databáze: | OpenAIRE |
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