Transforming growth factor-beta 1 as a signal for induction of cell death by apoptosis
| Autor: | A. F. Purchio, Wilfried Bursch, Bettina Grasl-Kraupp, F. Oberhammer, Roland Sedivy, Rolf Schulte-Hermann, R. L. Jirtle, M. Askari |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
Programmed cell death medicine.medical_specialty Necrosis medicine.medical_treatment Apoptosis Biology Transforming Growth Factor beta Internal medicine medicine Animals Cyproterone Acetate Hyperplasia Cell Death Growth factor Transforming growth factor beta Rats Endocrinology Oncology Liver Cancer research biology.protein Female Signal transduction medicine.symptom Immunostaining Biomarkers Transforming growth factor Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Cell death by apoptosis is a major determinant of growth of normal tissues and tumours. The present study aimed to elucidate signal factors involved in its regulation. Epithelial cells in control liver, during regression of cyproterone acetate induced liver hyperplasia, in liver (pre)neoplasia and in uterus undergoing apoptosis in vivo show immunostaining for transforming growth factor beta 1 (TGF-beta 1) as detected by anti-pre(266-278) TGF-beta 1 antibodies. Positive immunostaining is also seen in a few intact cells of hyperplastic, regressing liver apparently preparing for apoptosis, but is virtually not found in hepatocytes of normal or growing liver nor in cells undergoing death by necrosis. Recombinant latency associated protein (rLAP, dimer of the pro-region non-covalently associated with the mature region) complex and mature TGF-beta 1 induce apoptosis in isolated hepatocytes cultured in vitro. These findings suggest an involvement of TGF-beta 1 in the induction of apoptosis in certain epithelia in vivo. Images Figure 1 Figure 3 |
| Databáze: | OpenAIRE |
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