Synthesis and antifungal activities of novel 1,3-β- d -glucan synthase inhibitors. Part 1

Autor:	Takahide Watanabe, Toshikazu Yamazaki, Tomoaki Inoue, Yasuko Satoh, Kazuko Kobayashi, Kazunao Masubuchi, Takehiro Okada, Ikuo Horii, Eisaku Mizuguchi, Masahiro Aoki, Masahiro Sakaitani, Haruyoshi Shirai, Nobuo Shimma, Masami Kohchi, Osamu Kondoh
Rok vydání:	2001
Předmět:	Antifungal Agents Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Biochemistry Chemical synthesis Microbiology Aspergillus fumigatus Inhibitory Concentration 50 Lactones Mice Structure-Activity Relationship chemistry.chemical_compound Candida albicans Drug Discovery medicine Animals Combinatorial Chemistry Techniques Enzyme Inhibitors Molecular Biology Inclusion Bodies Depsipeptide chemistry.chemical_classification biology Chemistry Organic Chemistry Candidiasis Membrane Proteins Ornithine medicine.disease biology.organism_classification Anti-Bacterial Agents Survival Rate Disease Models Animal Enzyme Liver Therapeutic Equivalency Glucosyltransferases Enzyme inhibitor biology.protein Molecular Medicine Schizosaccharomyces pombe Proteins Systemic candidiasis Peptides
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 11:395-398
ISSN:	0960-894X
Popis:	Highly potent 1,3-β- d -glucan synthase inhibitors, 7b , 10a , 10b and 12 , have been identified by the chemical modification of the ornithine residue of a fungicidal macrocyclic lipopeptidolactone, RO-09-3655 ( 1 ), isolated from the cultured broth of Deuteromycotinia spp. These compounds showed stronger antifungal activity against systemic candidiasis as well as pulmonary aspergillosis in mice, and less hepatotoxicity as compared with 1 .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f374759851a3051aa561e0e41c116c5c https://doi.org/10.1016/s0960-894x(00)00678-8 Zobrazit plný text záznamu Full Text from ScienceDirect