Plasma Von Willebrand Factor Levels Predict Survival in COVID-19 Patients Across the Entire Spectrum of Disease Severity
| Autor: | K. Murugabharathy, Vineeth Varghese Thomas, George M. Varghese, Snehil Kumar, Lakshmanan Jeyaseelan, Ramya Iyyadurai, Balakrishnan Vijayalekshmi, Vijay Alexander, Ronald Albert Benton Carey, Kishore Pichamuthu, Ashish Goel, Sukesh C. Nair, Sheba Meriam Thomas, Anand Zachariah, Santhosh E. Kumar, Savit B. Prabhu, CE Eapen, Uday Zachariah, Ambily Nadaraj, K. P. P. Abhilash, Samuel George Hansdak |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Hematology biology Endothelium business.industry Reticulo-endothelial system COVID-19 Disease Odds ratio Von Willebrand factor Gastroenterology Confidence interval Ferritin Endothelial activation medicine.anatomical_structure Internal medicine biology.protein medicine Original Article business |
| Zdroj: | Indian Journal of Hematology & Blood Transfusion |
| ISSN: | 0974-0449 0971-4502 |
| Popis: | Background: Characterization of reticulo-endothelial activation in COVID-19 may guide treatment. Objectives: To assess reticulo-endothelial activation and its correlation with disease severity and death in patients across the entire spectrum of COVID-19 severity. Methods: Consecutive hospitalized COVID-19 patients were studied, with similar number of patients in each disease severity category. Baseline serum ferritin, sCD163 (macrophage activation markers) and plasma von Willebrand factor (VWF) antigen (endothelial activation marker) levels were studied. Clinical parameters and plasma D-dimer levels were also studied. The study parameters were correlated with COVID-19 severity and survival. Results: The 143 patients (104 males [80%], age 54 [42 – 65] years, median [inter-quartile range]) presented 4 (3—7) days after symptom onset. Thirty-four patients had mild disease, 36 had moderate disease, 36 had severe disease and 37 had critical disease at baseline. With increasing COVID-19 severity, ferritin, sCD163, VWF and D-dimer levels significantly increased at baseline, however, 139 patients had normal sCD163 levels. Of the reticulo-endothelial markers, VWF level independently correlated with COVID-19 severity and with survival. VWF level > 332.6 units/dl correlated with COVID-19 severity (odds ratio [OR]: 2.77 [95% confidence interval (C.I): 1.1 – 6.99], p value: 0.031) and in-hospital death (OR [95% CI]: 29.28 [5.2 – 165], p value |
| Databáze: | OpenAIRE |
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