Renin-Angiotensin-Aldosterone System and Sodium Balance in Experimental Renal Hypertension
| Autor: | Derek A. Denton, R. D. Wright, John P. Coghlan, J. R. Blair-West, Bruce A. Scoggins, Elspeth Orchard |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
medicine.medical_specialty
Hypertension Renal Natriuresis Blood Pressure Renal Artery Obstruction Nephrectomy Plasma renin activity Renovascular hypertension chemistry.chemical_compound Endocrinology Internal medicine Renin Renin–angiotensin system medicine Animals Aldosterone Sheep business.industry Angiotensin II Sodium Water-Electrolyte Balance medicine.disease Blood pressure chemistry Renal physiology Pathophysiology of hypertension business |
| Zdroj: | Endocrinology. 83:1199-1209 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-83-6-1199 |
| Popis: | Sheep were made chronically hypertensive by constriction of one renal artery. Blood levels of renin, aldosterone and cortisol were measured. Sodium balance was estimated from measured food intake and renal and fecal sodium loss. Animals with a clipped single kidney and animals with mild hypertension after unilateral clipping showed only a temporary increase of renin, aldosterone and cortisol in peripheral blood. Animals with severe hypertension after unilateral clipping became sodium depleted, due to increased renal excretion of sodium. Renin and aldosterone blood levels did not return to normal levels but increased progressively with the sodium deficit. The findings demonstrate that chronic renovascular hypertension is not necessarily associated with abnormal concentration of renin or aldosterone in peripheral blood, and suggest that the renin-angiotensin system is not the cause of the continuing hypertension. Severe hypertension may cause sodium depletion in animals with both kidneys in situ. The effect... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|