Autophagy modulation in cancer: Current knowledge on action and therapy
| Autor: | Ivana Novak, Maja Buljubašić, Mija Marinković, Matilda Šprung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging Article Subject Disease Review Article Biochemistry law.invention Malignant transformation 03 medical and health sciences Downregulation and upregulation law Chloroquine Neoplasms medicine Autophagy Animals Humans lcsh:QH573-671 business.industry lcsh:Cytology Cancer Cell Biology General Medicine medicine.disease 030104 developmental biology Drug development Cancer research Suppressor business autophagy autophagy modulators cancer cancer therapy clinical trials medicine.drug |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2018 (2018) |
| Popis: | In the last two decades, accumulating evidence pointed to the importance of autophagy in various human diseases. As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes. Both autophagy upregulation and downregulation have been found in cancers, suggesting its dual oncogenic and tumor suppressor properties during malignant transformation. Identification of the key autophagy targets is essential for the development of new therapeutic agents. Despite this great potential, no therapies are currently available that specifically focus on autophagy modulation. Although drugs like rapamycin, chloroquine, hydroxychloroquine, and others act as autophagy modulators, they were not originally developed for this purpose. Thus, autophagy may represent a new and promising pharmacologic target for future drug development and therapeutic applications in human diseases. Here, we summarize our current knowledge in regard to the interplay between autophagy and malignancy in the most significant tumor types: pancreatic, breast, hepatocellular, colorectal, and lung cancer, which have been studied in respect to autophagy manipulation as a promising therapeutic strategy. Finally, we present an overview of the most recent advances in therapeutic strategies involving autophagy modulators in cancer. |
| Databáze: | OpenAIRE |
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