Epizootiological and epidemiological study of hantavirus infection in Japan
| Autor: | Tetsuya Mizutani, Hiroshi Fukushima, Atsushi Tachi, Kazutaka Osawa, Shuji Ando, Kentaro Yoshii, Kimiyuki Tsuchiya, Kumari G. Lokugamage, Hiroshi Sato, Koichi Araki, Jiro Arikawa, Tomohiro Hagiya, Hiroaki Kariwa, Masahiro A. Iwasa, Ikuo Takashima, Nandadeva Lokugamage, Kumiko Yoshimatsu, Takuya Iwasaki |
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| Rok vydání: | 2004 |
| Předmět: |
Serotype
Veterinary medicine Orthohantavirus Rodent Hantavirus Infections Immunology Population Animals Wild Antibodies Viral Microbiology Rodent Diseases Japan Virology biology.animal Animals Humans education Hantavirus education.field_of_study biology Epizootiology biology.organism_classification Rats Muridae Apodemus Hantavirus Infection Seoul virus |
| Zdroj: | Microbiology and immunology. 48(11) |
| ISSN: | 0385-5600 |
| Popis: | Epizootiological surveys on hantavirus infections in rodents were carried out in various areas of Japan, including the four major islands of Hokkaido, Honshu, Shikoku, and Kyushu from 2000 to 2003. A total of 1,221 rodents and insectivores were captured. Seropositive animals were found in Apodemus (A.) speciosus (5/482, 1.0%), Rattus (R.) norvegicus (4/364, 1.1%), R. rattus (3/45, 6.7%), and Clethrionomys (C.) rufocanus (7/197, 3.6%). The partial S segment was amplified from one seropositive R. rattus captured at Hakodate. The nucleotide sequence showed 96% identity with the Seoul virus (SEOV) prototype strain SR-11. In addition, we conducted an epidemiological survey on human hantavirus infection in a high-risk population, the personnel of the Japan Ground Self-defense Force on Hokkaido. One out of 207 human blood samples was positive for anti-hantavirus antibody by IFA, ELISA, and WB analysis. The result of the serotype specific ELISA indicates that this individual acquired SEOV infection. This study indicates that A. speciosus, R. norvegicus, R. rattus, and C. rufocanus carry hantaviruses as the reservoir animals in Japan. Infected R. rattus and R. norvegicus in port areas could be the sources of human SEOV infection and a threat to travelers and individuals working in seaports. |
| Databáze: | OpenAIRE |
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