Histopathological Evaluation of the Efficacy of Antifungals for Experimental Trichosporon Bloodstream Infection
Autor: | Chikako Hasegawa, Naobumi Tochigi, Aki Mitsuda, Tsuyoshi Shimamura, Takao Ishiwatari, Somay Yamagata Murayama, Takashi Sugita, Takehiko Kaneko, Yoichiro Okubo, Kazutoshi Shibuya, Minoru Shinozaki, Megumi Wakayama, Tetsuo Nemoto, Daisuke Sasai |
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Rok vydání: | 2013 |
Předmět: |
Male
Microbiology (medical) Antifungal Agents Colony Count Microbial Inflammation Polyenes Kidney Microbiology Mice Trichosporon Amphotericin B Resistant strain Bloodstream infection Trichosporonosis Animals Medicine Effective treatment Fluconazole Histological examination Microbial Viability biology Histocytochemistry business.industry General Medicine biology.organism_classification Pathophysiology Disease Models Animal Infectious Diseases Macrolides medicine.symptom business Fungemia medicine.drug |
Zdroj: | Japanese Journal of Infectious Diseases. 66:133-139 |
ISSN: | 1344-6304 |
Popis: | The efficacy of polyene macrolides to treat experimental Trichosporon bloodstream infection was evaluated by histopathological examination and viable cell counts in the kidneys of infected mice. Viable cell counts on the 5th day after infection confirmed that liposomal amphotericin B (L-AMB) is a more effective treatment than fluconazole (FLC) for mice infected with an azole-resistant strain of Trichosporon. Histological examination revealed that the administration of L-AMB induced a transformation from acute purulent inflammation caused by both azole-susceptible and -resistant strain infections to a chronic and subsiding form, whereas FLC failed to convert the acute inflammation induced by the azole-resistant strain to a subsiding form. Our results demonstrate that polyene macrolides can be used as an alternative therapy for infection of azole-resistant strains of Trichosporon and that histopathological evaluation is useful for elucidating the pathophysiology of an experimental Trichosporon infection. |
Databáze: | OpenAIRE |
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