Mutation of the INI1 gene in composite rhabdoid tumor of the endometrium
| Autor: | Fan Zhang, Jaclyn A. Biegel, Ludvik R. Donner, Luanne M. Wainwright |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Pathology Chromosomal Proteins Non-Histone Molecular Sequence Data Biology medicine.disease_cause Polymerase Chain Reaction Article Pathology and Forensic Medicine Exon Cyclin D1 medicine Humans Allele In Situ Hybridization Fluorescence Rhabdoid Tumor Aged Mutation Base Sequence Anatomical pathology SMARCB1 Protein Middle Aged Cell cycle medicine.disease Endometrial Neoplasms DNA-Binding Proteins Cancer research Immunohistochemistry Female Spindle cell carcinoma Transcription Factors |
| Zdroj: | Human Pathology. 38:935-939 |
| ISSN: | 0046-8177 |
| Popis: | Composite rhabdoid tumors are typically adult tumors that contain a component of rhabdoid cells, which are characteristic of the aggressive childhood malignant rhabdoid tumor. Pediatric rhabdoid tumors are characterized by the inactivation of the hSNF5/INI1/SMARCB1 gene, with subsequent loss of expression of the protein. In contrast, only a single composite rhabdoid tumor has demonstrated involvement of the INI1 gene. In our study, INI1 protein expression was studied in two uterine carcinosarcomas with rhabdoid components (composite rhabdoid tumors). The rhabdoid component of one tumor showed lack of immunoreactivity for the INI1 protein and strong positivity for cyclin D1, while the adenocarcinomatous component of the tumor and both components of the second tumor were immunoreactive for the INI1 protein and negative for cyclin D1. Loss of one INI1 allele and a mutation in exon 7 of the remaining allele were detected in the first tumor, consistent with the immunohistochemistry results. Our results demonstrate that deletions and mutations of the INI1 gene can occur also in rare composite rhabdoid tumors of adulthood. Further studies are necessary, however, to determine the prognostic significance of this finding. |
| Databáze: | OpenAIRE |
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