Strong and Tough Mineralized PLGA Nanofibers for Tendon-to-bone Scaffolds
| Autor: | Wenying Liu, Younan Xia, Guy M. Genin, Stavros Thomopoulos, Pavan V. Kolluru, Justin Lipner, Ioannis Chasiotis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Scaffold
Toughness Materials science Biomedical Engineering Nanofibers macromolecular substances Biochemistry Article Bone and Bones Biomaterials Tendons chemistry.chemical_compound Tissue engineering Polylactic Acid-Polyglycolic Acid Copolymer Elastic Modulus Tensile Strength Ultimate tensile strength Materials Testing Lactic Acid Composite material Molecular Biology Elastic modulus Minerals Tissue Engineering Tissue Scaffolds General Medicine PLGA chemistry Nanofiber Elongation Polyglycolic Acid Biotechnology |
| Popis: | Engineering complex tissues such as the tendon-to-bone insertion sites require a strong and tough biomimetic material system that incorporates both mineralized and unmineralized tissues with different strengths and stiffnesses. However, increasing strength without degrading toughness is a fundamental challenge in materials science. Here, we demonstrate a promising nanofibrous polymer-hydroxyapatite system, in which, a continuous fibrous network must function as a scaffold for both mineralized and unmineralized tissues. It is shown that the high toughness of this material system could be maintained without compromising on the strength with the addition of hydroxyapatite mineral. Individual electrospun poly (lactide-co-glycolide) (PLGA) nanofibers demonstrated outstanding strain-hardening behavior and ductility when stretched uniaxially, even in the presence of surface mineralization. This highly desirable hardening behavior which results in simultaneous nanofiber strengthening and toughening was shown to depend on the initial cross-sectional morphology of the PLGA nanofibers. For pristine PLGA nanofibers, it was shown that ellipsoidal cross-sections provide the largest increase in fiber strength by almost 200% compared to bulk PLGA. This exceptional strength accompanied by 100% elongation was shown to be retained for thin and strongly bonded conformal mineral coatings, which were preserved on the nanofiber surface even for such very large extensions. |
| Databáze: | OpenAIRE |
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