Compound blue nevus: a reappraisal of the concept in the genomic era
| Autor: | Adrien Buisson, Julien Jaquemus, Véronique Haddad, Emilie Perron, Arnaud de la Fouchardière, Gerardo Ferrara |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Dorsum Adult Male Pathology medicine.medical_specialty Skin Neoplasms Adolescent Biology Pathology and Forensic Medicine 03 medical and health sciences Young Adult 0302 clinical medicine Nevus Blue Hotspot mutation medicine Humans Molecular Biology Blue nevus Aged Aged 80 and over GNA11 Cell Biology General Medicine Middle Aged GTP-Binding Protein alpha Subunits 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Mutation GTP-Binding Protein alpha Subunits Gq-G11 Melanocytes Female Epidermis medicine.symptom GNAQ |
| Zdroj: | Virchows Archiv : an international journal of pathology. 476(3) |
| ISSN: | 1432-2307 |
| Popis: | We report a series of 21 compound blue nevi, a rare variant in the vast clinical and morphological spectrum of blue melanocytic proliferations. Clinically, they presented in young adults, with a slight female predominance. One-third were located on the dorsum of the foot. Morphologically, all cases displayed large dendritic melanocytes restricted to the deep layers of the epidermis. The compound component was central and evenly distributed. Melanocytic density ranged from scarce isolated cells to a confluent lentiginous architecture. In 12 of the 21 cases, junctional nests of small, bland, weakly pigmented melanocytes were associated. These nests became confluent in the most cellular cases. In all cases, a dermal component was immediately present underneath, mainly of cellular blue nevus-type. All cases were genetically confirmed to harbor either a GNAQ or GNA11 hotspot mutation. This study expands the morphological spectrum of blue nevi that should not be restricted to a strictly intradermal melanocytic proliferation. |
| Databáze: | OpenAIRE |
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