Interplay of cGAS with chromatin
| Autor: | Marilena Wischnewski, Andrea Ablasser |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
i interferon
Computational biology Biology Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 2nd-messenger Animals Nucleosome Molecular Biology 030304 developmental biology 0303 health sciences Innate immune system Mechanism (biology) dinucleotide nucleosome Membrane Proteins structural basis DNA Nucleotidyltransferases Phenotype Chromatin 3. Good health Cyclic GMP-AMP cyclic gmp-amp synthase chemistry inflammation activation cytosolic dna sensor 030217 neurology & neurosurgery |
| Zdroj: | Elsevier |
| ISSN: | 0968-0004 |
| Popis: | Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the execution of innate immune mechanisms, both in contexts of infection as well as in noninfectious settings of cellular stress and injury. The indiscriminate ability of double-stranded DNA (dsDNA) to activate cGAS challenges our understanding on how engagement of this pathway is prevented on genomic self-DNA under homeostatic conditions. Here, we review recent discoveries on the regulation of cGAS on chromatin and we discuss implications for cGAS-dependent inflammatory phenotypes. We close by highlighting emerging developments on the role of nuclear cGAS and related open questions for future research. |
| Databáze: | OpenAIRE |
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