Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination
| Autor: | Russ Tsao, Mahender R. Alluri, George O. Morton, Joseph Ashcroft, Marshall M. Siegel, David R. Williams, Peter Northcote, Wei-Dong Ding, G. A. Ellestad, Darren Abbanat, William M. Maiese |
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| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
biology Streptomycetaceae Stereochemistry biochemical phenomena metabolism and nutrition medicine.disease_cause biology.organism_classification Antimicrobial Streptomyces Anti-Bacterial Agents Staphylococcus aureus Drug Discovery medicine Moiety Actinomycetales Macrolides Bacteria Antibacterial agent |
| Zdroj: | The Journal of antibiotics. 47(11) |
| ISSN: | 0021-8820 |
| Popis: | Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are the first natural products that contain the highly unsaturated pyrroloindole moiety. |
| Databáze: | OpenAIRE |
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