The Effect of Diosmin Hesperidin on Intestinal Ischaemia — Reperfusion Injury
| Autor: | S Kocak, S M Hazinedaroglu, Mevlut Pehlivan, T Keklik, Hüseyin Ayhan Kayaoğlu, A B Erkek, O Canbolat |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Ischemia Diosmin Ileum Pharmacology Rats Sprague-Dawley Lesion Hesperidin chemistry.chemical_compound medicine Animals Flavonoids biology business.industry General Medicine medicine.disease Malondialdehyde Rats Intestines Intestinal Diseases medicine.anatomical_structure chemistry Reperfusion Injury Anesthesia Myeloperoxidase Models Animal biology.protein Surgery medicine.symptom business Reperfusion injury medicine.drug |
| Zdroj: | Acta Chirurgica Belgica. 104:715-718 |
| ISSN: | 0001-5458 |
| DOI: | 10.1080/00015458.2004.11679649 |
| Popis: | The effect of Diosmin Hesperidin on intestinal ischaemia reperfusion injury was evaluated in an experimental model in rats.Forty Spraque-Dawley rats were divided into 4 groups of (n = 10) (sham, sham + Diosmin Hesperidin, Reperfusion, Reperfusion + Diosmin Hesperidin). Diosmin Hesperidin oral gavage was administrated at a dose of 50 mg/kg to rats 14 and 2 hours before the operation and 30 minutes of ischaemia and 30 minutes of reperfusion was performed in the groups when appropriate. Ileum samples were resected for histopathological evaluation and tissue malondialdehyde (MDA) and myeloperoxidase (MPA) level determination.Mean mucosal injury score of IR group (4,50+/-0,23) was significantly higher than the other groups (p0.05). Although mean mucosal injury score of IR + DH group was higher than sham and sham + DH groups, difference was not statistically significant (p0.05). Tissue MDA and MPO activities of IR group were 45,55+/-2.61 nmol/g/wet tissue and 1.68+/-0.25 U/g/wet tissue respectively and were significantly higher than the other groups (p0.008). Although tissue MDA and MPO activities of IR + DH group was higher than sham and sham + DH groups, differences were not statistically significant (p0.008).Diosmin Hesperidin seems to be effective in the prevention of intestinal reperfusion injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|