Regulation of the p53 Family Proteins by the Ubiquitin Proteasomal Pathway
| Autor: | Sandeep Kaur, Manabu Kurokawa, Scott Bang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cellular homeostasis
Review tp63 law.invention lcsh:Chemistry Mice 0302 clinical medicine Ubiquitin law Neoplasms Gene expression lcsh:QH301-705.5 Spectroscopy 0303 health sciences biology apoptosis General Medicine tp53 Computer Science Applications Cell biology Ubiquitin ligase Gene Expression Regulation Neoplastic 030220 oncology & carcinogenesis DNA damage Ubiquitin-Protein Ligases Protein degradation ubiquitination Catalysis Inorganic Chemistry 03 medical and health sciences Animals Humans cancer Physical and Theoretical Chemistry Molecular Biology 030304 developmental biology Tumor Suppressor Proteins Organic Chemistry Tumor Protein p73 tp73 e3 ligase lcsh:Biology (General) lcsh:QD1-999 Ubiquitin-Proteasomal Pathway Proteolysis Trans-Activators biology.protein Suppressor Tumor Suppressor Protein p53 Protein Processing Post-Translational |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 1, p 261 (2019) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | The tumor suppressor p53 and its homologues, p63 and p73, play a pivotal role in the regulation of the DNA damage response, cellular homeostasis, development, aging, and metabolism. A number of mouse studies have shown that a genetic defect in the p53 family could lead to spontaneous tumor development, embryonic lethality, or severe tissue abnormality, indicating that the activity of the p53 family must be tightly regulated to maintain normal cellular functions. While the p53 family members are regulated at the level of gene expression as well as post-translational modification, they are also controlled at the level of protein stability through the ubiquitin proteasomal pathway. Over the last 20 years, many ubiquitin E3 ligases have been discovered that directly promote protein degradation of p53, p63, and p73 in vitro and in vivo. Here, we provide an overview of such E3 ligases and discuss their roles and functions. |
| Databáze: | OpenAIRE |
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