Clinicopathological analysis of sinonasal malignant lymphoma in an HTLV-1 endemic area in Japan -special focus on primary sinonasal diffuse large B-cell lymphoma
| Autor: | Daisuke Murakami, Takashi Nakagawa, Yusuke Miyamoto, Tetsuya Koyama, Hirofumi Omori, Kaname Miyashita, Motohiro Sawatsubashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Adolescent medicine.medical_treatment diffuse large B-cell lymphoma chemotherapy Disease-Free Survival Malignant lymphoma 03 medical and health sciences 0302 clinical medicine Japan immune system diseases hemic and lymphatic diseases Medicine Humans human T-cell leukemia virus type 1 Aged Retrospective Studies Aged 80 and over Chemotherapy Human T-lymphotropic virus 1 Disease entity business.industry Endemic area General Medicine Sinonasal Tract Middle Aged medicine.disease Lymphoma primary sinonasal lymphoma Survival Rate Leukemia 030104 developmental biology 030220 oncology & carcinogenesis Original Article Female Lymphoma Large B-Cell Diffuse business Diffuse large B-cell lymphoma Paranasal Sinus Neoplasms |
| Zdroj: | Journal of Clinical and Experimental Hematopathology : JCEH |
| ISSN: | 1880-9952 1346-4280 |
| Popis: | The present study investigated histological subtypes of lymphoma in patients newly diagnosed with malignant lymphoma in the human T-cell leukemia virus type 1 (HTLV-1) endemic area of Japan, and further analyzed the clinicopathological features and clinical outcomes of patients with primary sinonasal lymphoma. We retrospectively examined 151 patients aged 18-90 years in Fukuoka, Japan. Subtypes of lymphoma were determined according to the WHO classification. Among the 151 patients, 104 were diagnosed with malignant lymphoma, including 96 at the time of initial diagnosis. Ninety-two of the 96 lymphomas (96%) were non-Hodgkin lymphoma. Mature B-cell neoplasms comprised 78% (n = 75). Primary lymphoma of the sinonasal cavity was found in six patients (6%). The histological subtype of sinonasal lymphoma was diffuse large B-cell lymphoma (DLBCL) in all six tumors. Furthermore, overall survival was significantly different among three distinct DLBCL patient groups, including primary sinonasal lymphoma patients (p = 0.0016; 3-year overall survival: sinonasal DLBCL group, 53%; DLBCL of the CNS group, 0%; other DLBCL group, 83%). Our study suggests that primary DLBCL of the sinonasal tract is a distinct disease entity of DLBCL. |
| Databáze: | OpenAIRE |
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