Nanoparticles with Dual Responses to Oxidative Stress and Reduced pH for Drug Release and Anti-inflammatory Applications
| Autor: | Younan Xia, Er-Tuan Chuang, Zi-Xian Liao, Hsing-Wen Sung, Yi Cheng Ho, Wei Lun Chiang, Min Suk Shim, Barnali Maiti, Hsiao Lan Pu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Drug Carriers Reactive oxygen species Lipopolysaccharide medicine.drug_class Anti-Inflammatory Agents General Engineering General Physics and Astronomy Hydrogen-Ion Concentration medicine.disease_cause Anti-inflammatory Oxidative Stress chemistry.chemical_compound Biochemistry chemistry Drug delivery Biophysics medicine Curcumin Nanoparticles General Materials Science Drug carrier Oxidative stress Reactive nitrogen species |
| Zdroj: | ACS Nano. 8:1213-1221 |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | Oxidative stress and reduced pH are involved in many inflammatory diseases. This study describes a nanoparticle-based system that is responsive to both oxidative stress and reduced pH in an inflammatory environment to effectively release its encapsulated curcumin, an immune-modulatory agent with potent anti-inflammatory and antioxidant capabilities. Because of the presence of Förster resonance energy transfer between curcumin and the carrier, this system also allowed us to monitor the intracellular release behavior. The curcumin released upon triggering could efficiently reduce the excess oxidants produced by the lipopolysaccharide (LPS)-stimulated macrophages. The feasibility of using the curcumin-loaded nanoparticles for anti-inflammatory applications was further validated in a mouse model with ankle inflammation induced by LPS. The results of these studies demonstrate that the proposed nanoparticle system is promising for treating oxidative stress-related diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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