Exposure to pesticide mixtures and DNA damage among rice field workers

Autor: Alvaro J. Idrovo, Ruth M. Palma-Parra, Marcela E. Varona-Uribe, Sonia M. Díaz-Criollo, Carlos H. Torres-Rey, Leonardo Briceño, Diana Marcela Devia Narvaez, Sandra Patricia Carmona
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Health
Toxicology and Mutagenesis
Carbamic acid derivative
Urine
010501 environmental sciences
Toxicology
medicine.disease_cause
01 natural sciences
chemistry.chemical_compound
Hydrocarbons
Chlorinated
Middle aged
Chemical mixtures
General Environmental Science
Ethylenethiourea
Aged
80 and over
Chemistry
food and beverages
Agriculture
Chlorinated hydrocarbon
Middle Aged
Occupational exposure
Dna damage
Blood
Cross-sectional studies
Malathion
Female
Comet Assay
Human
Adult
Organophosphorus compounds
Adolescent
Colombia
Young Adult
03 medical and health sciences
Organophosphorus Compounds
Occupational Exposure
medicine
Humans
Pesticides
Comet assay
Cross-sectional study
0105 earth and related environmental sciences
Aged
Drug effects
Adverse effects
Public Health
Environmental and Occupational Health
Very elderly
Oryza
Hexachlorobenzene
2 imidazolidinethione
Pesticide
Confidence interval
Hydrocarbons
Cross-Sectional Studies
030104 developmental biology
Young adult
chlorinated
Organophosphorus compound
Carbamates
Genotoxicity
Analysis
DNA Damage
Zdroj: Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Popis: This study describes the use of pesticides mixtures and their potential association with comet assay results in 223 rice field workers in Colombia. Thirty-one pesticides were quantified in blood, serum, and urine (15 organochlorines, 10 organophosphorus, 5 carbamates, and ethylenethiourea), and the comet assay was performed. Twenty-four (77.42%) pesticides were present in the workers. The use of the maximum-likelihood factor analysis identified 8 different mixtures. Afterwards, robust regressions were used to explore associations between the factors identified and the comet assay. Two groups of mixtures-?-benzene hexachloride (?-BHC), hexachlorobenzene (HCB), and ?-BHC (?: 1.21, 95% confidence interval [CI]: 0.33-2.10) and pirimiphos-methyl, malathion, bromophos-methyl, and bromophos-ethyl (?: 11.97, 95% CI: 2.34-21.60)-were associated with a higher percentage of DNA damage and comet tail length, respectively. The findings suggest that exposure to pesticides varies greatly among rice field workers. © 2016 Taylor and Francis.
Databáze: OpenAIRE
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