Carotid artery intima-media thickness and lacunar versus nonlacunar infarcts
| Autor: | Mauro Silvestrini, Giorgio Bernardi, Fabrizio Vernieri, Letizia M. Cupini, F. Ferrante, Marina Diomedi, Barbara Rizzato, Patrizio Pasqualetti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Brain Infarction
Male Tunica media medicine.medical_specialty Carotid Artery Common Central nervous system disease Age Distribution lacunar infarction Predictive Value of Tests Risk Factors medicine.artery medicine Humans cardiovascular diseases Myocardial infarction Common carotid artery Sex Distribution Ultrasonography Doppler Color Stroke Aged Aged 80 and over Advanced and Specialized Nursing Vascular disease business.industry Cerebral infarction ultrasonography Middle Aged medicine.disease Lacunar infarction Risk factors Ultrasonography Cross-Sectional Studies Logistic Models medicine.anatomical_structure Intima-media thickness Acute Disease cardiovascular system Settore MED/26 - Neurologia Female Neurology (clinical) Radiology Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine business |
| Popis: | Background and Purpose — Increases in the thickness of the intima and media of the carotid artery have been associated with an increased risk of myocardial infarction and stroke in subjects without a history of cardiovascular disease. Lacunar infarcts, one of the most common subtype of ischemic stroke, show unique pathological and clinicoradiological characteristics. The present study examines the relationship between vascular risk factors, including carotid artery intima-media thickness (IMT), and lacunar versus nonlacunar infarcts. Methods — We collected data from patients with acute ischemic stroke admitted to hospital. Patients and 129 control subjects underwent B-mode ultrasonographic measurements of IMT of the common carotid artery. We examined the association of lacunar and nonlacunar infarcts with age, sex, and potential vascular risk factors. Results — Of 292 adult patients with an acute first-ever ischemic stroke, 96 were considered lacunar and 196 were considered nonlacunar strokes. We did not find a significantly different percentage of diabetes, smoking, hypertension, dyslipidemia, myocardial infarction, and previous transient ischemic attack between the 2 groups of patients. The multinomial logistic regression procedure selected carotid artery IMT and atrial fibrillation as the only independent factors able to discriminate between lacunar and nonlacunar patients. IMT values were significantly higher in patients with nonlacunar stroke versus both those with lacunar stroke and control subjects. Conclusions — The present results indicate the usefulness of noninvasive measurement of IMT with ultrasonic techniques as a diagnostic tool that may help to identify different subtypes of ischemic stroke patients. The noninvasive measurements may have predictive power with respect to lacunar versus nonlacunar infarcts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|