Residual minor histocompatibility genes contaminate the B10.AM congenic line: no evidence of C-region-controlled histoincompatibility
| Autor: | Zoltan A. Nagy, Peter Walden, Antonio Juretic, N. Protrka, Jan Klein |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Genetics
Mice Inbred BALB C Mice Inbred C3H Minor Histocompatibility Loci Immunology Congenic Antibodies Monoclonal hemic and immune systems chemical and pharmacologic phenomena Locus (genetics) Mice Inbred Strains General Medicine Biology Molecular biology In vitro Histocompatibility CTL Mice Antigen Mice Inbred DBA Animals Allele Gene Alleles T-Lymphocytes Cytotoxic |
| Zdroj: | Scandinavian journal of immunology. 18(6) |
| ISSN: | 0300-9475 |
| Popis: | After being primed in vivo and restimulated in vitro, cytolytic T lymphocytes (CTL) were produced in the strain combinations B10.AM anti-B10.A(1R) and B10.A(1R) anti-B10.AM. Although the two strains differ in the chromosomal interval between the E alpha and the D loci, the CTL are not directed against antigens controlled by loci in this interval. Instead, the CTL detect minor histocompatibility (H) antigens controlled by loci that are not linked to H-2. The recognition of the antigens detected by the B10.AM anti-B10.A(1R) CTL is restricted by the Kk and Db molecules, but the CTL also cross-react with the Dd molecule (or a molecule controlled by a locus closely linked to Dd). The recognition of the antigens detected by these two CTL behave as if controlled by alleles at the same minor H locus or loci. This locus is distinct from H-2, and the B10.AM congenic line apparently retained a C3H-derived allele at this locus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text