Optogenetic inhibition of behavior with anion channelrhodopsins
| Autor: | Katarina Chlebikova, James C. Stewart, Tong-Wey Koh, Adam Claridge-Chang, Jia Yi Chua, Stanislav Ott, Joses Ho, Farhan Mohammad |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Rhodopsin Light Action Potentials Channelrhodopsin Biology Optogenetics Biochemistry Wing expansion 03 medical and health sciences Neural Pathways Animals Voltage-Dependent Anion Channels Neural system Molecular Biology Light exposure Neurons Behavior Animal Organisms Genetically Modified fungi Taste Perception Cell Biology 030104 developmental biology Neuronal circuits Drosophila Neuroscience Locomotion Biotechnology |
| Zdroj: | Nature Methods. 14:271-274 |
| ISSN: | 1548-7105 1548-7091 |
| Popis: | Optogenetics uses light exposure to manipulate physiology in genetically modified organisms. Abundant tools for optogenetic excitation are available, but the limitations of current optogenetic inhibitors present an obstacle to demonstrating the necessity of neuronal circuits. Here we show that anion channelrhodopsins can be used to specifically and rapidly inhibit neural systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, thus demonstrating their broad utility in the circuit analysis of behavior. |
| Databáze: | OpenAIRE |
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