Autoimmune glial fibrillary acidic protein astrocytopathy with lesions distributed predominantly in the entire spinal cord
| Autor: | Bing-Wei Zhang, Jinming Han, You-Ming Long, Hai-Yang Wang, Xue-Lin Li, Hao-Tian Zhao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Central nervous system Case Report lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid antibody medicine lcsh:Neurology. Diseases of the nervous system Pharmacology Autoimmune disease Glial fibrillary acidic protein biology medicine.diagnostic_test business.industry spinal cord autoimmune Magnetic resonance imaging Spinal cord medicine.disease astrocytopathy Dysphagia 030104 developmental biology medicine.anatomical_structure Neurology glial fibrillary acidic protein biology.protein Neurology (clinical) medicine.symptom Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Therapeutic Advances in Neurological Disorders, Vol 13 (2020) Therapeutic Advances in Neurological Disorders |
| ISSN: | 1756-2864 |
| Popis: | Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy has been considered a novel central nervous system autoimmune disease characterized by relapse and responsiveness to corticosteroid with a specific GFAP-Immunoglobulin G (IgG) being noted in cerebrospinal fluid. We report the case of a 21-year-old girl presenting with dysuria and weariness, who subsequently developed blurry vision, slight dysphagia, slurred speech, and sensory abnormality. GFAP-IgG was detected in her cerebrospinal fluid. Magnetic resonance imaging using both T2-weighted and contrast-enhanced T1-weighted images revealed a rare finding of lesions distributed mainly in the entire spinal cord rather than typical brain lesions. After treating with corticosteroids, her clinical symptoms were alleviated, and the spinal cord lesion enhancement was reduced. Our observations extend the clinical spectrum of autoimmune GFAP astrocytopathy. We suggest that rare distributed lesions in the entire spinal cord in patients with autoimmune GFAP astrocytopathy cannot be ignored by neurologists. The identification of potential atypical lesions broadens the understanding of autoimmune GFAP astrocytopathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|