Role of P53 and BCL-2 in high-risk breast cancer patients treated with adjuvant anthracycline-based chemotherapy
| Autor: | Claudio Botti, Maria Benevolo, Girolamo Del Monte, Simonetta Buglioni, Stefania Vasselli, Patrizia Vici, Paola Papaldo, Marcella Mottolese, Franco Di Filippo, Cecilia Nisticò |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Cyclophosphamide Anthracycline Receptor ErbB-2 medicine.medical_treatment Breast Neoplasms Disease-Free Survival Breast cancer Predictive Value of Tests Risk Factors Internal medicine Antineoplastic Combined Chemotherapy Protocols Adjuvant therapy Humans Medicine skin and connective tissue diseases Antineoplastic Agents Alkylating Survival analysis Aged Epirubicin Antibiotics Antineoplastic business.industry General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis Treatment Outcome Proto-Oncogene Proteins c-bcl-2 Chemotherapy Adjuvant Multivariate Analysis Cancer research Female Tumor Suppressor Protein p53 business Breast carcinoma Mastectomy medicine.drug |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 126:722-729 |
| ISSN: | 0171-5216 |
| Popis: | Purpose: Adjuvant therapy has become an integral component of the management of primary high-risk breast cancer patients. However, a considerable fraction of women receive no benefit from this treatment. This study investigates whether a number of biopathological factors can influence the outcome of patients submitted to adjuvant chemotherapy involving the use of high-dose epirubicin and cyclophosphamide. Methods: One hundred and fifty-seven primary breast cancer patients, considered at high risk according to the St. Gallen Meeting Consensus Conference, were evaluated immunohistochemically for estrogen, progesterone receptors, p53, bcl-2, HER-2/neu, and Ki-67, of which the results were correlated with patient outcome. Results: Results obtained demonstrated that p53 is a significant predictor of disease-free survival (DFS P |
| Databáze: | OpenAIRE |
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