Indomethacin inhibits the effects of oestrogen in the anterior pituitary gland of the rat
| Autor: | D. G. Rosental, Cherñavsky Ac, Speziale Ns, G. A. Machiavelli, J. A. Burdman |
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| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Pituitary gland medicine.drug_class Endocrinology Diabetes and Metabolism Indomethacin Alpha (ethology) Prostaglandin Arachidonic Acids Dinoprostone chemistry.chemical_compound Endocrinology Anterior pituitary Pituitary Gland Anterior Internal medicine medicine Animals Progesterone Aspirin Estradiol Cell growth Estrogen Antagonists Rats Inbred Strains Prolactin Rats medicine.anatomical_structure Receptors Estrogen chemistry Estrogen Arachidonic acid |
| Zdroj: | Journal of Endocrinology. 121:513-519 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.1210513 |
| Popis: | Two inhibitors of prostaglandin synthesis, indomethacin and aspirin, blocked the increase of oestrogen-binding sites in the nuclear subcellular fraction, an increase which occurs after the administration of oestradiol. Consequently the biological effects of oestrogens in the anterior pituitary gland of the rat (prolactin synthesis, concentration of progesteronebinding sites and cell proliferation) are diminished. The anterior pituitary gland synthesized prostaglandin F2α (PGF2α), PGE2 and PGD2 from arachidonic acid. This synthesis was blocked when indomethacin was added to the culture media. Oestrogen increased the concentration of PGE2: an increase that was partially prevented by indomethacin. Prostaglandins may have an important role on the effects of oestrogen in the anterior pituitary gland of the rat. Journal of Endocrinology (1989) 121, 513–519 |
| Databáze: | OpenAIRE |
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