Importance of Weight Loss Maintenance and Risk Prediction in the prevention of Type 2 Diabetes: Analysis of European Diabetes Prevention Study RCT
| Autor: | Pirjo Ilanne-Parikka, Edith J. M. Feskens, John C. Mathers, Martin White, Johan G. Eriksson, Matti Uusitupa, Jaakko Tuomilehto, Sirkka Keinänen-Kiukaanniemi, Ellen E. Blaak, Linda Penn, Mark Walker, Jaana Lindström, Annemieke Th den Boer |
|---|---|
| Přispěvatelé: | Clinicum, Department of General Practice and Primary Health Care, Diabetes and Obesity Research Program, Humane Biologie, RS: NUTRIM - R1 - Metabolic Syndrome |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Gerontology
Male obesity Health Screening Anatomy and Physiology Non-Clinical Medicine endocrine system diseases Nutrition and Disease Psychological intervention lcsh:Medicine Type 2 diabetes Cardiovascular law.invention Impaired glucose tolerance MELLITUS 0302 clinical medicine Endocrinology Randomized controlled trial Weight loss law life-style intervention Voeding en Ziekte adults follow-up PROGRAM 030212 general & internal medicine lcsh:Science Multidisciplinary Incidence (epidemiology) Incidence trial Middle Aged 3. Good health Europe LIFE-STYLE INTERVENTION OBESITY Hypertension Medicine impaired glucose-tolerance Female TRIAL Public Health medicine.symptom Risk assessment Behavioral and Social Aspects of Health BEHAVIOR Research Article Test Evaluation medicine.medical_specialty Clinical Research Design education 030209 endocrinology & metabolism Endocrine System 03 medical and health sciences IMPAIRED GLUCOSE-TOLERANCE Diagnostic Medicine Diabetes mellitus Internal medicine Weight Loss medicine Humans Clinical Trials Life Style Nutrition VLAG Diabetic Endocrinology Treatment Guidelines Health Care Policy behavior business.industry lcsh:R Health Risk Analysis nutritional and metabolic diseases ADULTS Diabetes Mellitus Type 2 medicine.disease Diabetes Mellitus Type 2 FIN-D2D fin-d2d Hyperglycemia 3121 General medicine internal medicine and other clinical medicine lcsh:Q program Preventive Medicine business FOLLOW-UP Screening Guidelines mellitus |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 2, p e57143 (2013) PLOS ONE, 8(2):e57143. Public Library of Science PLoS ONE, 8(2) PLoS ONE 8 (2013) 2 |
| ISSN: | 1932-6203 |
| Popis: | Background Prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D prevention by lifestyle intervention is effective. Pragmatic scalable interventions are needed, with evidence to efficiently target and monitor such interventions. We report pooled analyses of data from three European trial cohorts: to analyse T2D incidence, sustained weight loss and utility of risk predictors. Methods We analysed data on 749 adults with impaired glucose tolerance (278 men and 471 women, mean age 56 years, mean BMI 31 kgm−2) recruited between 1993 and 2003, and randomised to intensive lifestyle intervention (I) or lifestyle advice control (C). The intervention aimed to increase physical activity, modify diet, and promote weight loss≥5%. Using Cox-regression survival analysis, we assessed T2D incidence and the impact on T2D incidence of sustained weight loss, and of baseline cut-point values of FINDRISC score, fasting plasma glucose (FPG), and HbA1c. Results Mean follow-up duration was 3.1 years. T2D was diagnosed in 139 participants (I = 45/379, C = 94/370). Cumulative T2D incidence was 57% lower in the intervention compared with the control group (HR 0.42 (95% CI 0.29 to 0.60) P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|