Low circulating microRNA levels in heart failure patients are associated with atherosclerotic disease and cardiovascular-related rehospitalizations

Autor: Eugene Berezikov, Eline L. Vegter, Tiny Jaarsma, Peter van der Meer, Adriaan A. Voors, Ekaterina S. Ovchinnikova, Dirk J. van Veldhuisen
Přispěvatelé: Cardiovascular Centre (CVC), Stem Cell Aging Leukemia and Lymphoma (SALL), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Circulating microRNAs
Heart failure
Atherosclerosis
Biomarkers
Rehospitalization
Angiogenesis
030204 cardiovascular system & hematology
ANGIOGENESIS
ACTIVATION
0302 clinical medicine
Cardiac and Cardiovascular Systems
Endothelial dysfunction
Kardiologi
Atherosclerotic disease
General Medicine
Prognosis
Peripheral
TARGET
Disease Progression
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
EXPRESSION
medicine.medical_specialty
BIOMARKERS
BIOLOGY
Inflammation
Patient Readmission
03 medical and health sciences
INFLAMMATION
Internal medicine
microRNA
medicine
Humans
Circulating MicroRNA
Aged
Original Paper
business.industry
PERIPHERAL ARTERIAL-DISEASE
CLUSTER
medicine.disease
ENDOTHELIAL-CELLS
030104 developmental biology
business
Follow-Up Studies
Zdroj: Clinical Research in Cardiology
Clinical Research in Cardiology, 106(8), 598-609. SPRINGER HEIDELBERG
ISSN: 1861-0692
1861-0684
DOI: 10.1007/s00392-017-1096-z
Popis: Objective Circulating microRNAs (miRNAs) have been implicated in both heart failure and atherosclerotic disease. The aim of this study was to examine associations between heart failure specific circulating miRNAs, atherosclerotic disease and cardiovascular-related outcome in patients with heart failure. Methods The levels of 11 heart failure-specific circulating miRNAs were compared in plasma of 114 heart failure patients with and without different manifestations of atherosclerotic disease. We then studied these miRNAs in relation to biomarkers associated to atherosclerosis and to cardiovascular-related rehospitalizations during 18 months of follow-up. Results At least one manifestation of atherosclerotic disease was found in 70 (61%) of the heart failure patients. A consistent trend was found between an increasing number of manifestations of atherosclerosis (peripheral arterial disease in specific), and lower levels of miR-18a-5p, miR27a-3p, miR-199a-3p, miR-223-3p and miR-652-3p (all P amp;lt; 0.05). Target prediction and network analyses identified several interactions between miRNA targets and biomarkers related to inflammation, angiogenesis and endothelial dysfunction. Lower miRNA levels were associated with higher levels of these atherosclerosis-related biomarkers. In addition, lower miRNA levels were significantly associated with rehospitalizations due to cardiovascular causes within 18 months, with let-7i-5p as strongest predictor [HR 2.06 (95% CI 1.29-3.28), C-index 0.70, P = 0.002]. Conclusions A consistent pattern of lower levels of circulating miRNAs was found in heart failure patients with atherosclerotic disease, in particular peripheral arterial disease. In addition, lower levels of miRNAs were associated with higher levels of biomarkers involved in atherosclerosis and an increased risk of a cardiovascular-related rehospitalization. Funding Agencies|Netherlands CardioVascular Research Initiative: the Netherlands Heart Foundation; Dutch Federation of University Medical Centres; Netherlands Organization for Health Research and Development; Royal Netherlands Academy of Sciences; Netherlands Heart Foundation: Approaching Heart Failure By Translational Research Of RNA Mechanisms (ARENA) [CVON-2011-11]; Netherlands Heart Foundation [2000Z003]; Biosite France SAS, Jouy-en-Josas, France; Roche Diagnostics Nederland BV, Venlo, the Netherlands; Novartis Pharma BV, Arnhem, the Netherlands
Databáze: OpenAIRE
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