Prolactin and thyroid hormone levels are associated with suicide attempts in psychiatric patients
| Autor: | Alessandro Serretti, Paolo Girardi, Mario Palermo, Massimo Biondi, Roberto Tatarelli, Luisa De Risio, Sandra Campi, Gianluca Serafini, Fabrice Duval, Marco Innamorati, Vincenzo De Luca, Leo Sher, Antonio Del Casale, Sara Gibiino, Maurizio Pompili, Franco Montebovi |
|---|---|
| Přispěvatelé: | Pompili M, Gibiino S, Innamorati M, Serafini G, Del Casale A, De Risio L, Palermo M, Montebovi F, Campi S, De Luca V, Sher L, Tatarelli R, Biondi M, Duval F, Serretti A, Girardi P. |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male biological predictor medicine.medical_specialty Psychosis Cross-sectional study attempted suicide Suicide Attempted mood disorder Schizoaffective disorder biological predictors Risk Factors medicine Humans Bipolar disorder Psychiatry depression thyroid hormones Biological Psychiatry Aged Mental Disorders Not Otherwise Specified Odds ratio Middle Aged medicine.disease Confidence interval Prolactin Psychiatry and Mental health Cross-Sectional Studies Schizophrenia Triiodothyronine Female Psychology |
| Popis: | The aim of this study is to evaluate biological factors associated with recent suicidal attempts in a naturalistic sample. A total of 439 patients suffering from major depression disorder (MDD), bipolar disorder (BD) and psychotic disorders (schizophrenia, schizoaffective disorder and psychosis not otherwise specified), who were consecutively assessed in the Emergency Department of an Italian Hospital (January 2008–December 2009), were included. In the whole sample, suicide attempters and non-attempters differed with regard to free triiodothyronine (FT3) and prolactin values only. A univariate general linear model indicated significant effects of sex (F1;379¼ 9.29; P¼ 0.002), suicidal status (F1;379¼ 4.49; P¼0.04) and the interaction between sex and suicidal status (F1;379¼5.17; P¼ 0.02) on prolactin levels. A multinomial logistic regression model indicated that suicidal attempters were 2.27 times (odds ratio (OR)¼0.44; 95% confidence interval (95%CI): 0.23/0.82; P¼ 0.01) less likely to have higher FT3 values than non-attempters; while prolactin values failed to reach statistical significance (OR¼ 0.99; 95%CI: 0.98/1.00; P¼ 0.051). Both prolactin and thyroid hormones may be involved in a complex compensatory mechanism to correct reduced central serotonin activity. Further studies may help in understanding how these findings can be used by clinicians in assessing suicide risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|