The synergistic effect of FC gamma receptor IIa and interleukin-10 genes on the risk to develop systemic lupus erythematosus in Thai population
| Autor: | Orrawadee Hanvivatvong, Somchai Akkasilpa, J. Netsawang, J. Wongchinsri, W. Korkit, Jongkonnee Wongpiyabovorn, Yingyos Avihingsanon, Nattiya Hirankarn, P. Hanvivadhanakul |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Candidate gene Immunology Single-nucleotide polymorphism Biology Biochemistry Antigens CD Risk Factors Polymorphism (computer science) Genotype Genetics Genetic predisposition medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Genetic Predisposition to Disease skin and connective tissue diseases Genotyping Polymorphism Genetic Lupus erythematosus Receptors IgG Haplotype General Medicine Thailand medicine.disease Interleukin-10 Female |
| Zdroj: | Tissue Antigens. 68:399-406 |
| ISSN: | 1399-0039 0001-2815 |
| Popis: | Several linkage analyses have consistently shown that systemic lupus erythematosus (SLE) susceptible genes are located on chromosome 1q21-44. In this study, two major candidate genes, interleukin-10 (IL-10) and Fc gamma receptor IIa (FcgammaRIIa), within these regions were investigated in Thai SLE patients. The genotyping of three single-nucleotide polymorphisms (promoter area: -1082, -819 and -592) within IL-10 gene and one polymorphism (change amino acid at position 131) within FcgammaRIIa gene was determined in 195 SLE patients and 159 ethnically matched controls. The RR/RH genotypes of FcgammaRIIa were found to be significantly increased in SLE patients compared with healthy controls [OR = 2.01, 95% confidence interval (CI) = 1.28-3.14, P= 0.001]. Interestingly, the synergistic effect between RR/RH genotypes of FcgammaRIIa and ACC/ACC haplotype of IL-10 in susceptibility to SLE was observed (OR = 7.84, 95% CI = 1.60-52.04, P= 0.002). In addition, the FcgammaRIIa, RR homozygotes was also strongly associated with anticardiolipin antibody production (OR = 6.09, 95% CI = 1.38-30.54, P= 0.006). The result demonstrated that ACC haplotype of IL-10 gene and FcgammaRIIa R131 polymorphism can be used as marker for genetic susceptibility and severity to SLE in Thai population, particularly individuals carrying both specific genotypes. |
| Databáze: | OpenAIRE |
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