Facile Transformation of Benzocyclobutenones into 2,3-Benzodiazepines via 4π—8π Tandem Electrocyclic Reactions Involving Net Insertion of Diazomethylene Compounds
Autor: | Noriko Ohsawa, Hideo Nemoto, Yuji Matsuya |
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Rok vydání: | 2007 |
Předmět: | |
Zdroj: | ChemInform. 38 |
ISSN: | 1522-2667 0931-7597 |
Popis: | Efficient transformations of benzocyclobutenones into 2,3-benzodiazepines by a formal insertion of diazomethylene compounds are described. This sequential process includes nucleophilic addition of diazomethylene anion, oxy-anion accelerated o-quinodimethane formation by an electrocyclic ring-opening reaction, and 8pi-electrocyclization in one-pot under remarkably mild conditions. Intermediary oxy-anion plays an important role for the efficient transformations. |
Databáze: | OpenAIRE |
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