Serum levels of GM-CSF 20years after sulfur mustard exposure: Sardasht-Iran Cohort Study
| Autor: | Hassan Ghasemi, Soghrat Faghihzadeh, Mohammad R. Soroush, Athar Moin, Roya Yaraee, Hassan Salimi, Sara Amiri, Zuhair Mohammad Hassan, Shahryar Pourfarzam, Jalaleddin Shams, Tooba Ghazanfari, Zarin Sharifnia, Massoumeh Ebtekar |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Lung Diseases
medicine.medical_specialty Time Factors medicine.medical_treatment Immunology Enzyme-Linked Immunosorbent Assay Iran Gastroenterology Proinflammatory cytokine Cohort Studies chemistry.chemical_compound Immune system Blood serum Internal medicine Mustard Gas medicine Humans Immunology and Allergy Chemical Warfare Agents Pharmacology business.industry Granulocyte-Macrophage Colony-Stimulating Factor Interleukin Sulfur mustard medicine.anatomical_structure Cytokine chemistry Cytokines business Respiratory tract Cohort study |
| Zdroj: | International Immunopharmacology. 9:1499-1503 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2009.08.023 |
| Popis: | Sulfur mustard (SM) is highly toxic for various organs. The eyes, skin, respiratory tract, as well hematopoietic and immune systems are the main organs affected by SM. Granulocyte-macrophage colony stimulating factor (GM-CSF) is a potent cytokine that plays an important role in the hematopoietic and immune system. The aim of this study was to determine the serum levels of GM-CSF and its relation to blood cell count and other inflammatory cytokines 20 years after SM exposure. The association of GM-CSF with the clinical severity of pulmonary, ophthalmic and dermatologic complications has also been studied. In this historical cohort study named as Sardasht-Iran Cohort Study (SICS), 369 SM exposed male participants and 125 unexposed volunteers were studied. The serum concentrations of cytokines were measured by ELISA technique. The severity of clinical complications was graded according to the criteria verified by the Medical Committee of the Foundation of Martyr and Veterans Affairs. The serum levels of GM-CSF in the SM exposed group did not display any significant differences with the control group. Median of GM-CSF was 7.33 and 9.39 pg/ml in the SM exposed group and the controls respectively. There was a positive correlation between the serum levels of GM-CSF and the percent of eosinophils only in the exposed group. Moreover, positive correlations were found between circulating levels of GM-CSF with IL-1α, IL-1β, TNF-α and IL-6. This correlation was not observed between GM-CSF and IL-8 in both study groups. The serum levels of GM-CSF did not show any significant association with clinical complications. |
| Databáze: | OpenAIRE |
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