Diagnosis of bronchiectasis and airway wall thickening in children with cystic fibrosis: Objective airway-artery quantification
| Autor: | Hadiye Ozturk, Kazem Nasserinejad, Marleen de Bruijne, Jens Petersen, Wieying Kuo, Harm A.W.M. Tiddens, Adria Perez-Rovira, Yong Chen |
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| Přispěvatelé: | Pediatrics, Radiology & Nuclear Medicine, Medical Informatics, Epidemiology, Hematology |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Cystic Fibrosis Paediatric lung disease Airway dimensions Bronchi Pulmonary Artery Cystic fibrosis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Humans Medicine Radiology Nuclear Medicine and imaging Lung volumes Child Lung Imaging/CT Retrospective Studies Neuroradiology Observer Variation Bronchiectasis business.industry General Medicine respiratory system medicine.disease respiratory tract diseases Peripheral medicine.anatomical_structure 030228 respiratory system Exhalation Spirometry Chest Radiographic Image Interpretation Computer-Assisted Female Radiology Tomography X-Ray Computed business Airway Artery |
| Zdroj: | European Radiology, 27(11), 4680-4689. Springer-Verlag European Radiology Kuo, W, de Bruijne, M, Petersen, J, Nasserinejad, K, Ozturk, H, Chen, Y, Perez-Rovira, A & Tiddens, H A W M 2017, ' Diagnosis of bronchiectasis and airway wall thickening in children with cystic fibrosis : objective airway-artery quantification ', European Radiology, vol. 27, no. 11, pp. 4680-4689 . https://doi.org/10.1007/s00330-017-4819-7 |
| ISSN: | 0938-7994 |
| DOI: | 10.1007/s00330-017-4819-7 |
| Popis: | Objectives To quantify airway and artery (AA)-dimensions in cystic fibrosis (CF) and control patients for objective CT diagnosis of bronchiectasis and airway wall thickness (AWT). Methods Spirometer-guided inspiratory and expiratory CTs of 11 CF and 12 control patients were collected retrospectively. Airway pathways were annotated semi-automatically to reconstruct three-dimensional bronchial trees. All visible AA-pairs were measured perpendicular to the airway axis. Inner, outer and AWT (outer−inner) diameter were divided by the adjacent artery diameter to compute AinA-, AoutA- and AWTA-ratios. AA-ratios were predicted using mixed-effects models including disease status, lung volume, gender, height and age as covariates. Results Demographics did not differ significantly between cohorts. Mean AA-pairs CF: 299 inspiratory; 82 expiratory. Controls: 131 inspiratory; 58 expiratory. All ratios were significantly larger in inspiratory compared to expiratory CTs for both groups (p |
| Databáze: | OpenAIRE |
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