Is the Corrected-Creatinine Model for End-Stage Liver Disease a Feasible Strategy to Adjust Gender Difference in Organ Allocation for Liver Transplantation?
| Autor: | Chin-Wen Chi, Pui Ching Lee, Samantha C. Huo, Han Chieh Lin, Shou-Dong Lee, Teh Ia Huo, Fan Wei Tseng |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Time Factors Tissue and Organ Procurement Scoring system medicine.medical_treatment Renal function Lower priority Liver transplantation Models Biological Gastroenterology chemistry.chemical_compound Liver disease Model for End-Stage Liver Disease Internal medicine Humans Medicine Aged Aged 80 and over Sex Characteristics Transplantation Creatinine business.industry Mortality rate Middle Aged medicine.disease Liver Transplantation Surgery body regions chemistry Female business |
| Zdroj: | Transplantation. 84:1406-1412 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/01.tp.0000282867.92367.d0 |
| Popis: | BACKGROUND The Model for End-stage Liver Disease (MELD) scoring system is used for organ allocation in liver transplantation. Female cirrhotic patients have lower glomerular filtration rates (GFR) than males for the same creatinine (Cr) level. Correcting the Cr in females for the same GFR as in males shows that females have lower MELD scores and therefore a lower priority for liver transplantation; however, there has been no outcome data that justifies this modification. METHODS We investigated 472 cirrhotic patients, comparing the mortality rate between males and females in relation to MELD and corrected-Cr MELD. RESULTS Compared to females, male patients had a higher MELD (14.5+/-5.5 vs. 13.8+/-5.7) and significantly higher GFR (61.7+/-21.4 vs. 54.7+/-25.6 mlLmin/1.73 m, P=0.0002) because their Cr value was higher (1.4+/-0.4 vs. 1.3+/-0.5 mg/dL, P=0.0002). The corrected-Cr MELD score in females was higher (15.7+/-6.3) compared to the MELD in their original counterpart (P |
| Databáze: | OpenAIRE |
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