Factors associated with misdiagnosis of frozen section of mucinous borderline ovarian tumor

Autor: Jinhua Leng, Yang Xiang, Junjun Yang, Wen Zhang, Congwei Jia, Shuangzheng Jia
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Adult
Medicine (General)
medicine.medical_specialty
endocrine system diseases
Clinical Research Reports
Gene Expression
030204 cardiovascular system & hematology
Biochemistry
Stromal Invasion
03 medical and health sciences
Ovarian tumor
R5-920
0302 clinical medicine
Mucinous borderline ovarian tumor
Risk Factors
Clinical endpoint
Biomarkers
Tumor
Medicine
Frozen Sections
Humans
Antigens
Tumor-Associated
Carbohydrate
Nuclear atypia
misdiagnosis
Risk factor
Diagnostic Errors
Large diameter
permanent pathology
Retrospective Studies
Ovarian Neoplasms
Frozen section procedure
business.industry
mucinous malignant ovarian tumor
Biochemistry (medical)
Membrane Proteins
Retrospective cohort study
Cell Biology
General Medicine
Middle Aged
frozen section
Adenocarcinoma
Mucinous
Carcinoembryonic Antigen
risk factor
030220 oncology & carcinogenesis
CA-125 Antigen
Multivariate Analysis
Female
Radiology
business
Zdroj: The Journal of International Medical Research
Journal of International Medical Research, Vol 47 (2019)
ISSN: 1473-2300
0300-0605
Popis: Borderline ovarian tumors (BOTs), a kind of indolent neoplasm characterized by the presence of cellular proliferation and nuclear atypia in the absence of destructive stromal invasion, account for 10% to 20% of all epithelial ovarian tumors.1 Compared with their invasive counterparts, BOTs are characterized by an early stage at diagnosis and an excellent prognosis.2 Moreover, up to 45% of women with BOTs are younger than 40 years.1,3 However, only 29% to 69% of patients with BOTs can be correctly diagnosed preoperatively,4 and the discriminative capacity is limited even for prediction models of BOTs.5–7 Thus, an accurate intraoperative frozen section (FS) diagnosis plays a crucial role in determining the appropriate surgical procedure for BOTs. During the past two decades, considerable efforts have been made to increase the diagnostic accuracy of FS of BOTs. However, only 62.8% to 87.0% of FS-diagnosed BOTs can be confirmed by the final pathology,8–10 and this rate is even poorer for mucinous BOTs (mBOTs) because of their large diameter and high heterogeneity.11 A misdiagnosis of BOTs may result in unnecessary surgical staging in benign cases and restaging procedures in early-stage malignant tumors; this is particularly important for young women wishing to preserve their childbearing capacity.12 Unfortunately, the diagnostic accuracy of FS of mBOTs has been poorly studied. Most studies that have explored this parameter mainly included mucinous tumors as part of an analysis of the entire group of ovarian masses or BOTs, and any diagnostic disagreement was attributed to the mBOTs.13 Thus, the primary endpoint of our retrospective study was to investigate the diagnostic accuracy of FS of mBOT. The secondary endpoint was to analyze the factors associated with misdiagnosis of FS of mBOT.
Databáze: OpenAIRE
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