Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy.. A 12-year experience
| Autor: | Humberto Reyes, Dolores Tohá, Rodrigo Zapata, Juan Silva, Jose Ribalta, Joaquín Palma, Ismael Hernandez, Manuel Sedano, Lorena Sandoval |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Cholagogues and Choleretics medicine.medical_specialty Cholestasis Intrahepatic Gastroenterology Cholestasis Pregnancy Internal medicine Outpatients medicine Fetal distress Humans In patient Aspartate Aminotransferases Adverse effect Retrospective Studies Inpatients Hepatology business.industry Pruritus Ursodeoxycholic Acid Pregnancy Outcome Alanine Transaminase Retrospective cohort study gamma-Glutamyltransferase medicine.disease Ursodeoxycholic acid Pregnancy Complications Female business Cholestasis of pregnancy medicine.drug |
| Zdroj: | LIVER INTERNATIONAL Artículos CONICYT CONICYT Chile instacron:CONICYT |
| ISSN: | 1600-0676 1478-3223 |
| Popis: | Objective: To assess the efficacy of ursodeoxycholic acid (UDCA) in patients with intrahepatic cholestasis of pregnancy (ICP) and in the outcome of pregnancy. Methods: Retrospective analysis of our 12-year experience treating ICP patients with UDCA. Thirty-two patients with pruritus starting before week 34 of pregnancy and with increased serum bile salts (BS) and alanine aminotransferase (ALT) received UDCA (15 mg/kg/day) for at least 3 weeks before delivery. They were compared with 16 historical controls who did not receive UDCA. All patients were followed up until delivery and in puerperium. Newborns were followed up during 3 months. Results: UDCA treatment attenuated pruritus (P |
| Databáze: | OpenAIRE |
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